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Molecular detection of antimalarial resistance in Plasmodium vivax isolates from a tertiary care setting in Puducherry.
Indian J Med Microbiol
March 2024
Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantri Nagar, Puducherry, 605006, India; Department of Microbiology, ESIC Medical College& PGIMSR, Chennai, 78, India. Electronic address:
Purpose: The study was aimed at detecting the mutation patterns in the drug targets in Plasmodium vivax that confer resistance to the common antimalarial agents used in India.
Methods: A total of 27 Plasmodium vivax isolates collected from whole blood samples over a three year period were subjected to PCR amplification followed by sequencing of the genes pvmdr1, pvdhfr, pvdhps and pvk12, which serve as the molecular targets to detect resistance to chloroquine, pyrimethamine, sulfadoxine and artemisinin respectively.
Results: The study found T958 M F1076L double mutants of pvmdr1 in 52 %(14/27) isolates, S58R S117 N double mutants of pvdhfr in 67 % (18/27) isolates, A383G A553G double mutant pvdhps in 59 % (16/27) isolates and wild type of pvk12 gene in all the isolates.
New insights into the spread of resistance to artemisinin and its analogues.
J Glob Antimicrob Resist
December 2021
Department of Chemistry, Islamia College University, Peshawar 25120, Pakistan. Electronic address:
Plasmodium falciparum, the causative agent of malaria, has been developing resistance to several drugs worldwide for more than five decades. Initially, resistance was against drugs such as chloroquine, pyrimethamine, sulfadoxine, mefloquine and quinine. Research studies are now reporting parasites with resistance to the most effective and novel drug used against malaria infection worldwide, namely artemisinin.
View Article and Find Full Text PDFThe Malaria TaqMan Array Card Includes 87 Assays for Plasmodium falciparum Drug Resistance, Identification of Species, and Genotyping in a Single Reaction.
Antimicrob Agents Chemother
May 2017
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
Antimalarial drug resistance exacerbates the global disease burden and complicates eradication efforts. To facilitate the surveillance of resistance markers in countries of malaria endemicity, we developed a suite of TaqMan assays for known resistance markers and compartmentalized them into a single array card (TaqMan array card, TAC). We included 87 assays for species identification, for the detection of mutations associated with chloroquine, atovaquone, pyrimethamine, sulfadoxine, and artemisinin resistance, and for neutral single nucleotide polymorphism (SNP) genotyping.
View Article and Find Full Text PDFThe efficacy of Sulphadoxine/Pyrimethamine (SP) in Plasmodium falciparum malaria treatment was increasingly compromised by development of parasites' resistance. Saudi Arabia shifted to new combinations including Artesunat compound during the last decade. We investigated the occurrence of mutations in P.
View Article and Find Full Text PDFDrugs for the treatment of malaria in the Kingdom of Saudi Arabia.
Saudi Med J
June 2013
Department of Biology, King Fahd University of Petroleum and Minerals, PO Box 468, Dhahran 31261, Kingdom of Saudi Arabia.
Current malaria treatments are based on the use of artemisinin based combinations. In the Kingdom of Saudi Arabia, the combination of pyrimethamine/sulfadoxine/artesunate is the first line of treatment of uncomplicated malaria, while lumefantrine/artemether (Coartem) is used as a second option. The treatment of severe malaria rests on the use of quinine or artesunate.
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