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Levothyroxine malabsorption following sleeve gastrectomy.
Endocrinol Diabetes Metab Case Rep
January 2025
Summary: Oral levothyroxine (LT4) is prescribed worldwide for hypothyroidism. Bariatric surgery for patients with obesity has shown a substantial, long-term weight loss and considerable improvement of obesity-related diseases. LT4 malabsorption represents a significant cause of refractory hypothyroidism, well known after malabsorptive bariatric surgery such as Roux-en-Y gastric bypass.
View Article and Find Full Text PDF[Vacuum ultraviolet laser dissociation and proteomic analysis of halogenated peptides].
Se Pu
February 2025
CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Chemical modifications are widely used in research fields such as quantitative proteomics and interaction analyses. Chemical-modification targets can be roughly divided into four categories, including those that integrate isotope labels for quantification purposes, probe the structures of proteins through covalent labeling or cross-linking, incorporate labels to improve the ionization or dissociation of characteristic peptides in complex mixtures, and affinity-enrich various poorly abundant protein translational modifications (PTMs). A chemical modification reaction needs to be simple and efficient for use in proteomics analysis, and should be performed without any complicated process for preparing the labeling reagent.
View Article and Find Full Text PDFEvaluating the potential for iodinated radiocontrast agents to interfere with ADAMTS13 activity testing via fluorescence resonance energy transfer methodology.
Am J Clin Pathol
December 2024
Special Coagulation Laboratory, Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, US.
Objectives: Fluorescence resonance energy transfer (FRET)-based ADAMTS13 activity assays are critical for the diagnosis of thrombotic thrombocytopenic purpura. However, these assays are susceptible to interference. As iodide has been suggested to interfere in laboratory testing via fluorophore quenching or promotion, we aimed to determine whether iodinated contrast (Omnipaque) interferes with the ATS-13 ADAMTS13 Activity Assay 2.
View Article and Find Full Text PDFMeasurement of trace I in natural water with ozone reaction for effective separation of spectral interferences.
iScience
December 2024
National Metrology Institute of Japan, National Institute of Advanced Industrial Sciences and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8563, Japan.
Tandem quadrupole inductively coupled plasma mass spectrometry has the potential capability to measure I at extremely low concentration if spectral interferences from Xe and IH can be eliminated effectively. Ozone was introduced as the reaction gas, resulting significantly improved reactions of (I→IO) and (I→IO ), and permitted the highly sensitive measurement of I as IO and IO , helping eliminate spectral interferences related to Xe and IH . In isotopic ratio (I/I) analysis by measuring (I→IO )/(I→IO ), a blank ratio of 6.
View Article and Find Full Text PDFModeling and assessment of radioactive iodine dispersion inside Egyptian radioisotope production facility.
Appl Radiat Isot
October 2023
Department of Mechanical Engineering, Faculty of Engineering, Monoufiya University, Egypt.
Indoor Air Quality (IAQ) is very important topic in any radioisotope production facility. It is mandatory for some operators to be available behind hot cell that produce radioisotope to practice some tasks concerning maintenance, dosimetry and operation. One of these tasks is redundant transferring Radioiodine from cell to quality control lab and vice versa for measurements.
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