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RTN4IP1 Contributes to ESCC via Regulation of Amino Acid Transporters.
Adv Sci (Weinh)
January 2025
Department of Pathophysiology, School of Basic Medical Sciences, The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, State Key Laboratory of Esophageal, Cancer Prevention and Treatment, Provincial Cooperative Innovation Center for Cancer Chemoprevention, China-US (Henan) Hormel Cancer Institute, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, 450000, China.
Esophageal squamous cell carcinoma (ESCC) accounts for about 90% of esophageal cancer cases. The lack of effective therapeutic targets makes it difficult to improve the overall survival of patients with ESCC. Reticulon 4 Interacting Protein 1 (RTN4IP1) is a novel mitochondrial oxidoreductase.
View Article and Find Full Text PDFAprotic electrolytes beyond organic carbonates: transport properties of LiTFSI solutions in sulphur based solvents.
ChemSusChem
December 2024
University of Rome La Sapienza, Department of Chemistry, P.le A. Moro 5, 00185, Rome, ITALY.
This work illustrates a physico-chemical study of the structural, dynamic, and transport properties of electrolytes made of LiTFSI solutions in sulphoxide and sulphone solvent mixtures. Experimental measurements, by Raman and NMR spectroscopies, as well as electrochemical impedance spectroscopy, reveal the formation of a variety of ionic aggregates depending on the solvent composition that significantly affect the ion mobility and conductivity of the electrolyte. Mixtures containing tetrahydrothiophene-1-oxide exhibit a larger ion mobility due to a rapid exchange mechanism between solvent molecules, whereas the use of tetramethylene sulphone favors the formation of ionic aggregates due to the strong dipolar interactions between solvent molecules.
View Article and Find Full Text PDFAldo-keto reductase family 1 member B10 prevents esophageal squamous cell carcinoma from reactive carbonyl species-induced cell death and promotes its progression.
Cancer Cell Int
December 2024
Department of Applied Chemistry, Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Puli, Taiwan.
Introduction: Chronic alcohol consumption and tobacco usage are major risk factors for esophageal squamous cell carcinoma (ESCC). Excessive tobacco and alcohol consumption lead to oxidative stress and the generation of reactive carbonyl species (RCS) which induce DNA damage and cell apoptosis. This phenomenon contributes to cell damage and carcinogenesis in various organs including ESCC.
View Article and Find Full Text PDFSynthesis and Properties of Thermostable Energetic Benzotriazines.
J Org Chem
January 2025
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
In an effort to balance energy and molecular stability effectively, several energetic compounds (-) based on benzotriazine were designed and synthesized. These structures were comprehensively characterized using NMR, IR, and elemental analysis, with compounds , , and further confirmed by single-crystal X-ray diffraction. Notably, 3-amino-5,7-dinitrobenzo[][1,2,4]triazine 1-oxide (), which features a face-to-face crystal stacking arrangement, exhibits good detonation velocity ( = 8050 m/s), a high thermal decomposition temperature ( = 290 °C), and low sensitivities (impact sensitivity >40 J, friction sensitivity >360 N).
View Article and Find Full Text PDFCaspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma.
Proc Natl Acad Sci U S A
December 2024
Centre for Gene Therapy and Regenerative Medicine, School of Basic and Medical Biosciences, King's College London, London SE1 9RT, United Kingdom.
Oral squamous cell carcinoma (OSCC) is a subtype of head and neck cancer that arises in the multilayered epithelia of the mouth and lips. Although inactivating mutations in are frequently found in human OSCC their role in the disease is unknown. To investigate this, we deleted in the oral epithelium of adult mice.
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