1. Mouse fibroblast L-cells susceptible to methoprene and to a synthetic C18 juvenile hormone were cultivated for several months in the medium with one of these compounds at a subeffective concentration (10 microgram/ml) then allowed to grow in the medium with the particular compound at an effective concentration (20 microgram/ml). 2. This resulted in establishing the cells whose mitotic activity, morphology, pattern of growth and the rate of macromolecular biosynthesis (even after cultivation for several months in the presence of methoprene or the hormone at originally effective concentration) did not differ from those for control cells.
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