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Objective: Aim: To analyze the mechanisms of regulation of the body's proteolytic systems during inflammation, detection of inflammation markers in blood and prostate secretions in the experimental benign prostatic hyperplasia in rats.
Patients And Methods: Materials and Methods: The study was conducted on 30 male rats on the model of benign prostatic hyperplasia. Rats were randomized as following: the 1st group (n=6) - intact animals; the 2nd group (n=24) - rats with benign prostatic hyperplasia.
A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors.
PLoS Comput Biol
November 2024
CSL Ltd, Bio21 Institute, Melbourne, Victoria, Australia.
Background: The kallikrein-kinin system (KKS) is a complex biochemical pathway that plays a crucial role in regulating several physiological processes, including inflammation, coagulation, and blood pressure. Dysregulation of the KKS has been associated with several pathological conditions such as hereditary angioedema (HAE), hypertension, and stroke. Developing an accurate quantitative model of the KKS may provide a better understanding of its role in health and disease and facilitate the rapid and targeted development of effective therapies for KKS-related disorders.
View Article and Find Full Text PDFExploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview.
Toxins (Basel)
October 2024
Laboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, Darcy Ribeiro Campus, University of Brasília, Asa Norte, Brasilia 70910-900, DF, Brazil.
Article Synopsis
- * These serine proteases are similar in structure across different species and share high sequence similarity, even though they target different substrates.
- * The review aims to summarize extensive research on these enzymes, highlighting their biochemical diversity, structural features, evolutionary background, extraction methods, and potential biotechnological uses.
A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema.
Front Allergy
September 2024
Takeda Development Center Americas Inc., Cambridge, MA, United States.
Article Synopsis
- Cleaved high-molecular-weight kininogen (HKa) serves as a biomarker for the activation of the kallikrein-kinin system (KKS) in patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1INH).
- The study aimed to create an HKa-specific enzyme-linked immunosorbent assay (ELISA) for monitoring KKS activation in the blood of HAE-C1INH patients, utilizing a specific antibody found through phage display.
- Results showed that HKa levels were significantly higher in HAE-C1INH patients during attacks compared to healthy controls, indicating the potential of this ELISA for advancing drug development and understanding related diseases.
Targeting factor XIIa for therapeutic interference with hereditary angioedema.
J Intern Med
October 2024
University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Article Synopsis
- * Current treatments for HAE need improvement in effectiveness, quality of life, and fewer side effects, making FXIIa an appealing target for new therapies.
- * Garadacimab, a monoclonal antibody that inhibits FXIIa, is the most promising treatment in clinical trials, showing potential as a long-term solution for HAE, with further research suggested for its applications in other conditions.
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