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universal stress protein contributes to persistence during growth arrest and paraquat-induced superoxide stress.
J Bacteriol
January 2025
Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Unlabelled: is one of the most virulent bacterial pathogens known and causes the disease tularemia, which can be fatal if untreated. This zoonotic and intracellular pathogen is exposed to diverse environmental and host stress factors that require an appropriate response to survive. However, the stress tolerance mechanisms used by to persist are not fully understood.
View Article and Find Full Text PDFIdentification and characterisation of two functional antibiotic MATE efflux pumps in the archaeon Halorubrum amylolyticum.
NPJ Antimicrob Resist
August 2024
Biofilm Research Group, School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Multidrug efflux pumps have been found to play a crucial role in drug resistance in bacteria and eukaryotes. In this study, we investigated the presence of functional multidrug and toxic compound extrusion (MATE) efflux pumps, inferred from whole genome sequencing, in the halophilic archaeon Halorubrum amylolyticum CSM52 using Hoechst 33342 dye accumulation and antimicrobial sensitivity tests in the presence and absence of efflux pump inhibitors (EPIs). The whole genome sequence of H.
View Article and Find Full Text PDFGreen magnetically separable molluscicide Ba-Ce-Cu ferrite/TiO nanocomposite for controlling terrestrial gastropods Monacha Cartusiana.
Sci Rep
January 2025
Key Laboratory of Marine Ecosystem Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, 36 Baochubei Road, Hangzhou, 310012, People's Republic of China.
The increasing economic damage caused by terrestrial gastropods, especially the Monacha cartusiana (M. cartusiana) land snail, to the agricultural sector requires a diligent and continuous search for new materials and alternatives for the control operations. In this piece of work, a magnetically separable molluscicide with high effectiveness green Barium-Cerium-Copper ferrite/TiO (Ba-Ce-CuFO/TiO) nanocomposite was greenly prepared using Eichhornia plant aqueous extract and characterized using different techniques.
View Article and Find Full Text PDFRecent advances on dioxin and furan (dibenzofuran) based pollutants from analytical, environmental, and health perspectives.
Chemosphere
January 2025
Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, P.O. Box 26666, Sharjah, United Arab Emirates.
Dioxins and analogous derivatives pose significant concerns due to their impact on human health through both acute and prolonged exposures. They have the potential to resist natural degradation processes; therefore, they tend to accumulate in water, sediments, fish, meat, and human adipose tissue. As a result, concerns to both environmental and human health arise among the scientific community and environmental health organizers.
View Article and Find Full Text PDFExcipients in drug delivery systems: A comprehensive review of approved inactive ingredients for human ophthalmic formulations.
Eur J Pharm Biopharm
January 2025
Inserm UMRS_1138, Team 1, Physiopathology of ocular diseases: Therapeutic Innovations at Centre de Recherche des Cordeliers, Paris, France, 75006; Ophthalmopole at Hôpital Cochin, Paris, France; Sorbonne Paris Cité, UMRS_1138, France. Electronic address:
Pharmaceutical excipients, commonly known as inactive ingredients, encompass any substance aside from the active ingredient that fulfills a distinct and vital role in a formulation. Their purpose is to enhance specific characteristics, whether associated with the performance of the formulation or aspects related to patient comfort, safety, and acceptability. Because of the limited toxicity studies provided, and the several allergic and toxic side effects that have been reported throughout the years, it is not trivial for the regulatory agencies to approve inactive ingredients for human use.
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