AI Article Synopsis
- Sixty-four healthy infants aged 2-3 months were divided into three groups to receive different vaccines: DPT, PRP, or PRP + P.
- The DPT vaccine led to the highest rate of local and systemic reactions, while the PRP vaccine alone caused the least reactions.
- Among the infants receiving PRP + P, 70% showed a significant increase in antibody levels, indicating effective protection against invasive H. influenzae type b disease, compared to under 10% for those receiving the PRP vaccine alone.
Article Abstract
64 healthy infants 2-3 months old, were randomly assigned to one of three vaccination groups which received either diphtheria-pertussis-tetanus (DPT) vaccine, Haemophilus influenzae type b capsular polysaccharide polyribosyl-ribitol phosphate (PRP) vaccine, or PRP + P (with pertussis adjuvant) vaccine in three doses at intervals of 2 months. Local and systemic reactions occurred most frequently after DPT vaccination and least frequently for PRP alone. Data for 60 infants from whom complete sera sets were available indicated that 70% of the infants who received three doses of PRP + P showed 2-fold or greater increases in titres of antibody to PRP with final values above the level assumed to give protection against invasive H. influenzae type b disease (greater than or equal to 0.15 microgram/ml). In contrast, less than 10% of the infants who received PRP vaccine alone showed 2-fold or greater increases.
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| http://dx.doi.org/10.1016/s0140-6736(81)91045-x | DOI Listing |
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