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Physicochemical properties and in vitro hypolipidemic activities of three different bonding state pectic polysaccharide fractions extracted sequentially from pear pulp.
Int J Biol Macromol
January 2025
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China. Electronic address:
In this study, water-soluble fraction (WSF), chelator-soluble fraction (CSF), and sodium carbonate-soluble fraction (NSF) were sequentially fractionated from pear pulp, of which physicochemical properties and hypolipidemic activities in vitro were evaluated. They showed distinct monosaccharide composition, surface morphology, nuclear magnetic resonance (NMR), and Fourier transform infrared (FT-IR) spectrums. WSF and NSF were identified as high methyl-esterified pectic polysaccharides with degrees of methyl esterification (DM) of 85.
View Article and Find Full Text PDFEnhanced electrical conductivity and antibacterial properties of bacterial cellulose composite membrane decorated with hydroxypropyl-β-cyclodextrin/magnetic particle/alpha-lipoic acid/nano silver.
Int J Biol Macromol
January 2025
School of Textiles and Clothing, Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China. Electronic address:
The electrical conductivity and antibacterial properties are crucial characteristics for bacterial cellulose (BC) based membranes to be broadly applied in the field of wearable electronics. In the study, to achieve these aims, alpha-lipoic acid (LA) was utilized as anchoring groups and reducing agent, hydroxypropyl-β-cyclodextrin (HP-β-CD) capped magnetic particles (FeO NPs) and the in-situ formed silver nanoparticles (AgNPs) were sequentially incorporated into the BC matrix to fabricate BC based nanocomposite membranes (HP-β-CD/FeO/LA@BC and HP-β-CD/FeO/LA/Ag@BC). Fourier transform attenuated total reflectance infrared spectroscopy (FTIR-ATR) and field emission scanning electron microscopy (FE-SEM) analysis proved the dense networks were formed in the modified BC membranes.
View Article and Find Full Text PDFAdaptive promising zone design for sequential parallel comparison design with continuous outcomes.
Clin Trials
January 2025
Department of Biostatistics, University of Florida, Gainesville, FL, USA.
Introduction: The sequential parallel comparison design has emerged as a valuable tool in clinical trials with high placebo response rates. To further enhance its efficiency and effectiveness, adaptive strategies, such as sample size adjustment and allocation ratio modification can be employed.
Methods: We compared the performance of Jennison and Turnbull's method and the Promising Zone approach for sample size adjustment in a two-phase sequential parallel comparison design study.
Comparison of Different Thromboprophylaxis Regimens in Elderly Patients Following Hip Arthroplasty.
Br J Hosp Med (Lond)
January 2025
Department of Osteoarthritis, Yantai City Yantai Shan Hospital, Yantai, Shandong, China.
Deep venous thrombosis (DVT) represents a significant postoperative complication after artificial femoral head replacement, with the incidence increasing proportionally with patient age. This study aimed to evaluate the effect of early postoperative use of intermittent pneumatic compression devices (IPC), followed by the combined use of low molecular weight heparin (LMWH) after 48 hours, for the prevention of postoperative lower limb DVT in elderly patients undergoing hip arthroplasty. The retrospective study included 100 elderly patients who underwent unilateral femoral head replacement.
View Article and Find Full Text PDFNanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs.
Pharmaceutics
January 2025
CDL Research, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.
Background/objectives: Glioblastoma is the most common and lethal primary brain tumor. Patients often suffer from tumor- and treatment induced vasogenic edema, with devastating neurological consequences. Intracranial edema is effectively treated with dexamethasone.
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