Information is given on a long-term observation of gMT activities in the blood of cattle, aimed at using the results to interpret metabolic tests, especially tests of the function of liver. Dynamics of changes in the gMT activities was studied in the year seasons and the per cent activities in the decades (from 20 to 100 U per 1) in different groups of cows according to their reproduction cycle. In the part discussion relationships are given between the gMT activities and other findings obtained from metabolic tests. The average value of the gMT activities in the blood of a reference group of cows was 30.7 U per 1. The standard deviation was 7.01 U per 1. Reference limits for the gMT activities in the bovine blood serum - 16.7 to 44.7 U per 1 (95% interval of confidence) could be determined by a parametric statistical method. Average deviations of the gMT activities from those in the reference group of cows, expressed in histogram units J, ranged from 0.03 to 1.07 J after a long-term observation in particular calendar months. The maximum positive deviations were observed in January, June, July, November and they indicate the risk period, in August and September the values nearly approached those in the reference group of cows. The maximum positive deviation of the metabolic test amounted to 6.8 J (January). There were eight metabolic tests with the deviation greater than 1 J during the observation, two in the summer period (May--October) and six in the winter period (November-April). In cows after calving and in the first half of gravidity the gMT activities were most frequently in the decade 30.5-40.0 U per 1, and in highly pregnant cows in the decade 20.5-30.0 U per 1.
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PLoS One
January 2025
Radiant Research Services Pvt. Ltd., Bangalore, India.
1-Methylxanthine (1-MX) is the major metabolite of caffeine and paraxanthine and might contribute to their activity. 1-MX is an adenosine receptor antagonist and increases the release and survivability of neurotransmitters; however, no study has addressed the potential physiological effects of 1-MX ingestion. The aim of this study was to compare the effect of 1-MX on memory and related biomarkers in rats compared to control.
View Article and Find Full Text PDFJ Int Soc Sports Nutr
December 2025
Department of Health and Human Performance, Nova Southeastern University, Davie, FL, USA.
Position Statement: The International Society of Sports Nutrition (ISSN) presents this position based on a critical examination of the literature surrounding the effects of long-chain omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on exercise performance, recovery, and brain health. This position stand is intended to provide a scientific foundation for athletes, dietitians, trainers, and other practitioners regarding the effects of supplemental ω-3 PUFA in healthy and athletic populations. The following conclusions represent the official position of the ISSN: Athletes may be at a higher risk for ω-3 PUFA insufficiency.
View Article and Find Full Text PDFVaccine
February 2025
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Introduction: While it remains impossible to predict the timing of the next influenza pandemic, novel avian influenza A viruses continue to be considered a significant threat.
Methods: A Phase II study was conducted in healthy adults aged 18-64 years to assess the safety and immunogenicity of two intramuscular doses of pre-pandemic 2017 influenza A(H7N9) inactivated vaccine administered 21 days apart. Participants were randomized (n = 105 in each of Arms 1-3) to receive 3.
Int J Obes (Lond)
January 2025
Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA.
Background: The effects of time-restricted eating (TRE) with exercise on body composition in adults are not clear.
Objective: This meta-analysis aimed to assess the effects of TRE when followed in combination with various forms of exercise, including aerobic, resistance, and combined aerobic and resistance [concurrent] training on body composition.
Methods: Studies published up to May 2023 were searched in EBSCOhost (MEDLINE, CINAHL, SPORTSDISCUS), PubMed, and SCOPUS databases.
Expert Rev Vaccines
December 2025
Center for Clinical Trial of Vaccines, Hubei Institute for Infectious Disease, Control and Prevention, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China.
Background: LYB001 is a recombinant protein COVID-19 vaccine displaying a receptor-binding domain (RBD) in a highly immunogenic array on virus-like particles (VLPs). This study assessed the immunogenicity and safety of LYB001 as a booster.
Research Design And Methods: In this randomized, active-controlled, double-blinded, phase 3 trial, participants aged ≥ 18 years received a booster with LYB001 or ZF2001 (Recombinant COVID-19 Vaccine).
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