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Developing a knowledge transfer and exchange strategy for a clinical trials unit.
Trials
January 2025
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, UCL, 90 High Holborn, London, WC1V 6LJ, UK.
Need For A Strategic Approach To Knowledge Transfer And Exchange: Late-phase clinical trials and systematic reviews find results that have the potential to improve health outcomes for people. However, there are often delays in these results influencing clinical practice. We developed a knowledge transfer and exchange strategy to support research teams, aiming to identify activities along the research process to maximise and accelerate the research impact.
View Article and Find Full Text PDFControlling enzyme activity by mutagenesis and metal exchange to obtain crystal structures of stable substrate complexes of Class 3 l-asparaginase.
FEBS J
January 2025
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland.
Rhizobium etli is a nitrogen-fixing bacterium that encodes two l-asparaginases. The structure of the inducible R. etli asparaginase ReAV has been recently determined to reveal a protein with no similarity to known enzymes with l-asparaginase activity, but showing a curious resemblance to glutaminases and β-lactamases.
View Article and Find Full Text PDFThe interactive use of augmented reality for educating the elderly on common age-related eye disease.
BMC Geriatr
January 2025
Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Background: The prevalence of age-related eye disorders is increasing with the aging of the global population. Community-based visual health education for the elderly has become a crucial intervention. With the advancement of technology, the application of extended reality (XR), such as virtual reality (VR) and augmented reality (AR), in health education has become more popular.
View Article and Find Full Text PDFOptimization of in vitro propagation and virus eradication using meristem culture and thermotherapy in two geranium species Pelargonium X hortorum ('Zonal') and Pelargonium × domesticum ('Regal').
BMC Plant Biol
January 2025
Department of Plant Production and Genetic (Biotechnology), Faculty of Agriculture, Jahrom University, Jahrom, Iran.
Background: Geraniums (Pelargonium) are among the most popular flowers worldwide. Viral infection is one of the main problems of the genus Pelargonium, and the production of virus-free mother plants is necessary for large-scale geranium propagation and exchange. Meristem culture and thermotherapy are two effective procedures that have been widely adopted to produce healthy virus-free plant stocks.
View Article and Find Full Text PDFAI decodes CNNM Na/Mg exchange.
Structure
January 2025
Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA. Electronic address:
In this issue of Structure, Ma et al. apply the artificial intelligence system AlphaFold2, which was designed to predict three-dimensional protein structures from amino acid sequences with atomic accuracy, to model the conformal dynamics of the prokaryotic TpCorC and human CNNM2 and CNNM4 transporters, providing mechanistic insight into how sodium drives magnesium efflux.
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