A summary is given of the results obtained in experimental transmission of jaagsiekte by means transplantation of cell cultures. Evidence is also presented of transformation as the mechanism of oncogenesis and possibility of a viral aetiology is discussed briefly.
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Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development.
BMC Vet Res
January 2025
Department of Veterinary Pathology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
Background: Ovine pulmonary adenocarcinoma (OPA) is caused by Jaagsiekte sheep retrovirus (JSRV) and is considered an important potential animal model for human lung cancer. The precise mechanisms of OPA oncogenesis are still uncertain. The transcription factor signal transducer and activator of transcription 3 (STAT3) is activated by interleukin-6 (IL-6) in many cancers, but this aspect is unknown in OPA.
View Article and Find Full Text PDFAssociation between genetic clades and cancer prevalence suggested by French-wide study of oncogenic small ruminant β-retrovirus diversity.
Front Cell Infect Microbiol
November 2024
Viral Infections and Comparative Pathology (IVPC) UMR754, Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (INRAE), Universite Claude Bernard Lyon 1, École Pratique des Hautes Études (EPHE), Université Paris Sciences & Lettres (PSL), Lyon, France.
Introduction: ENTV (Enzootic Nasal Tumor Virus) and JSRV (Jaagsiekte Sheep Retrovirus) are β-retroviruses responsible for respiratory cancers in sheep and goats. In this study, we analyzed the genetic features of the sheep and goat β-Retroviruses (29 JSRV and 24 ENTV strains) circulating in France to identify molecular signatures associated with disease severity in flocks.
Methods: We developed a highly specific PCR to amplify and sequence exogenous targeted regions or near full length proviruses based on limited discriminating motifs along their genomes.
Establishment and validation of a real-time fluorescent PCR freeze-dried type assay for 11 sheep and goats pathogens.
Vet J
December 2024
Bioinformatics Center of Academy of Military Medical Sciences, Haidian, Beijing 100039, PR China. Electronic address:
Article Synopsis
- Small ruminants play a crucial role in food security in developing countries, but outbreaks of diseases pose significant risks to their health and economic value.
- A high-sensitivity real-time fluorescent PCR assay was developed for the detection of 11 pathogens affecting sheep and goats, ensuring accuracy and reliability in diagnosis.
- The assay demonstrated remarkable stability and longevity, remaining effective at room temperature for at least 567 days, even after rigorous testing at elevated temperatures.
Identification of concurrent infection with Jaagsiekte sheep retrovirus and maedi-visna virus in China.
J Vet Sci
September 2024
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot 010018, China.
Importance: Ovine pulmonary adenomatosis (OPA) and maedi-visna disease (MVD) are chronic and progressive infectious diseases in sheep caused by Jaagsiekte sheep retrovirus (JSRV) and maedi-visna virus (MVV), respectively.
Objective: To investigate the pathological changes and conduct viral gene analysis of OPA and MVD co-occurrence in Inner Mongolia, China.
Methods: Using gross pathology, histopathology, immunohistochemistry, ultrastructural pathology, PCR, and sequence analysis, we investigated the concurrent infection of JSRV and MVV in 319 Dorper rams slaughtered in a private slaughterhouse in Inner Mongolia, in 2022.
Tracking Ovine Pulmonary Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep Retrovirus Infection Model.
Genes (Basel)
August 2024
The Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush, Roslin, Edinburgh EH25 9RG, UK.
Article Synopsis
- Ovine pulmonary adenocarcinoma (OPA) is a serious lung disease in sheep that affects their health and costs farmers money.* -
- Scientists created a model to study OPA by giving sheep a virus called JSRV, and they found that different amounts of the virus led to various types of tumors.* -
- They used imaging techniques like CT scans and ultrasounds to monitor the tumors, discovering that these tools can effectively track the disease's progress, which helps improve research.*
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