Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
DNA Imprinting and Differentially Expressed Genes in Muscle of Submitted to Early Weaning Management.
Epigenomes
December 2024
School of Veterinary and Animal Science (FMVZ), São Paulo State University (Unesp), Botucatu 18618-681, SP, Brazil.
Early weaning management followed by energy supplementation can lead to metabolic alterations in the calf that exert long-term effects on the animal's health and performance. It is believed that the main molecular basis underlying these metabolic adaptations are epigenetic mechanisms that regulate, activate, or silence genes at different stages of development and/or in response to different environmental stimuli. However, little is known about postnatal metabolic programming in .
View Article and Find Full Text PDFG-protein-coupled receptor 41 in cardiomyocytes: Effect of butyrate on intracellular Ca and sarcomere shortening.
FASEB J
December 2024
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G-protein-coupled receptor 41 (GPR41) is a Gα-coupled receptor activated by short-chain fatty acids (SCFAs). Here, we tested that GPR41 is also expressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrate. Primary cardiomyocytes were isolated from wild-type (WT) and GPR41 knockout (GPR41) adult mice and intracellular Ca concentration and cell shortening were measured using the IonOptix system.
View Article and Find Full Text PDFInhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.
Sci Adv
December 2024
Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Cyclic nucleotide-dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat a range of noninfectious human disorders. Here, we report three subseries of fast-acting and potent PDEβ inhibitors that block asexual blood-stage parasite development and that are also active against human clinical isolates.
View Article and Find Full Text PDFSex-dimorphic glucose transporter-2 regulation of cAMP-protein kinase A (PKA) C-alpha pathway activity and phosphorylation in rat hypothalamic primary astrocyte cultures.
Eur J Neurosci
December 2024
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, USA.
Brain astrocyte glycogenolysis is regulated in part by the second messenger adenosine 3'5'-cyclic monophosphate (cAMP). Hypothalamic astrocyte glycogen metabolism shapes glucose counterregulation, under the control of glucose transporter-2 (GLUT2), a plasma membrane glucose carrier and sensor. Hypothalamic astrocyte cAMP is subject to neurotransmitter control, but effects of nutrient cues on this messenger are unclear.
View Article and Find Full Text PDFEpac1 activation optimizes cellular functions of BMSCs and promotes wound healing via Erk/ACLY/PGC-1α signaling pathway.
Eur J Pharmacol
December 2024
Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 710032, Xi'an, China. Electronic address:
Restrained cell function of relocated bone marrow mesenchymal stem cells (BMSCs) largely impedes the clinical benefits of BMSCs-mediated tissue repair. Exchange protein directly activated by cAMP (Epac), a novel protein discovered in cAMP signaling pathway, has a potential role in regulating cell migration and proliferation by triggering the downstream Rap signaling. However, whether and how Epac may exert effects on BMSCs' bioactivity have less been investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!