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The proximity ligation-based Hi-C and derivative methods are the mainstream tools to study genome-wide chromatin interactions. These methods often fragment the genome using enzymes functionally irrelevant to the interactions per se, restraining the efficiency in identifying structural features and the underlying regulatory elements. Here we present Footprint-C, which yields high-resolution chromatin contact maps built upon intact and genuine footprints protected by transcription factor (TF) binding.
View Article and Find Full Text PDFRisk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study.
BMC Pregnancy Childbirth
December 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, People's Republic of China.
Background: Ectopic pregnancy (EP) accounts for approximately 2% of all pregnancies, with tubal ectopic pregnancies (TEPs) being the most common type. Methotrexate (MTX) is a noninvasive and effective medical management option for TEP, but failure rates range from 10 to 36%, posing challenges in clinical practice. Identifying risk factors for MTX treatment failure is crucial to improve patient outcomes and guide clinical decision-making.
View Article and Find Full Text PDFHigh water iodine levels are associated with the prevalence of subclinical hypothyroidism, thyroid nodules and goiter among pregnant women in Shandong, China.
J Nutr
December 2024
Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, 300070, China; Tianjin Medical University General Hospital, Tianjin, 300070, China; Tianjin Environmental, Nutrition and Public Health Center, Tianjin, 300070, China. Electronic address:
Background: Both iodine deficiency and iodine excess can harm the thyroid glands during pregnancy. In areas without iodine fortification, the relationship between the water iodine concentration (WIC) and thyroid disease in pregnant women requires further investigation.
Objective: The aim of this study was to evaluate the relationship between water iodine levels and the prevalence of thyroid disease in pregnant women residing in areas with high water iodine levels without access to iodized salt.
In vitro evaluation of frozen thawed kangayam bull semen enriched with antioxidants.
Pol J Vet Sci
September 2024
Department of Clinics, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Namakkal-637 001, India.
The aim of this study was to assess the in vitro penetration rate of antioxidant enriched frozen thawed Kangayam bull semen. For the current investigation, 5-7-year-old Kangayam bulls were used. The semen was collected twice per week and two ejaculates were collected each time.
View Article and Find Full Text PDFDiagnostic Value of the Ovarian-Adnexal Reporting and Data System Ultrasound in Ovarian Masses: A Two-Center Study.
Br J Radiol
December 2024
Ultrasound Department, Fourth Affifiliated Hospital of Harbin Medical University, Surgeon's Hall, No. 37, Yiyuan Road, Nangang District, Harbin City, Heilongjiang prov, China.
Objective: This study aimed to assess the diagnostic efficacy of the Ovarian-Adnexal Reporting and Data System (O-RADS) and Ultrasound (US) and its sub-classification system for distinguishing ovarian masses.
Methods: O-RADS US was used for the retrospective analysis of 606 ovarian masses of Chinese from two medical centers by two gynecologic sonographers with varying experience. The O-RADS 4 categories masses were further sub-classified into O-RADS 4a and O-RADS 4 b through three different approaches(O-RADS A1/A2/A3).
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