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Similar Publications

Typical Atrial Flutter: A Practical Review.

J Cardiovasc Electrophysiol

January 2025

Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.

Typical atrial flutter (AFL), defined as cavotricuspid isthmus (CTI)-dependent macro-re-entrant atrial tachycardia, often causes debilitating symptoms, and is associated with increased incidence of atrial fibrillation, stroke, heart failure, and death. Typical AFL occurs in patients with atrial remodeling and shares risk factors with atrial fibrillation. It is also common in patients with a history of prior heart surgery or catheter ablation.

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Introduction: Unipolar radiofrequency (RF) ablation using half-normal saline irrigation (UNIP-HNS) and bipolar RF ablation using normal saline irrigation (BIP-NS) are effective to treat arrhythmias from inside thick myocardium. However, differences between these two ablations when using a long application time had not fully been studied.

Methods: UNIP-HNS, BIP-NS and unipolar RF ablation using normal saline irrigation (UNIP-NS) were applied for 120 s (30 W and 20-g contact) to porcine endocardial wall (≧15.

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Objective: The pathophysiological role of the small conductance calcium-activated potassium (SK) channels in human ventricular myocytes remains unclear. Experimental studies have reported upregulation of in pathological states, potentially contributing to ventricular arrhythmias. In heart failure (HF) patients, the upregulation of SK channels could be an adaptive physiological response to shorten the action potential duration (APD) under conditions of reduced repolarization reserve.

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Article Synopsis
  • Pulsed field ablation (PFA) shows promise for treating ventricular tachycardia (VT) in patients with ischemic cardiomyopathy, potentially overcoming limitations of traditional radiofrequency (RF) methods.
  • Two case studies demonstrated that PFA effectively halted VT and restored normal heart rhythm in one patient, while the other experienced VT recurrences after discharge, necessitating a follow-up RF procedure.
  • Results indicated that while PFA can treat large areas of damaged heart tissue quickly, challenges with catheter control may impact the effectiveness of the treatment.
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