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Seasonal Variations in Testicular Torsion: A Retrospective Study.
Cureus
December 2024
Department of Emergency Medicine, Jordan University of Science and Technology, Irbid, JOR.
Background: Testicular torsion (TT) is a urological emergency requiring prompt intervention to prevent irreversible damage to the testicle.
Objective: This study aims to assess trends in men's TT referrals, diagnostic evaluation through Doppler sonography (DS) scan, symptoms before surgery, orchidectomy rates, and TT laterality in relation to age and seasons of the year.
Methods: This observational retrospective cohort study included all patients treated for TT at King Abdullah University Hospital between 2009 and 2021.
Generation of bovine decellularized testicular bio-scaffolds as a 3D platform for testis bioengineering.
Front Bioeng Biotechnol
January 2025
Department of Agricultural and Environmental Sciences - Production, Landscape, Agroenergy, Università degli Studi di Milano, Milan, Italy.
Accelerating the genetic selection to obtain animals more resilient to climate changes, and with a lower environmental impact, would greatly benefit by a substantial shortening of the generation interval. One way to achieve this goal is to generate male gametes directly from embryos. However, spermatogenesis is a complex biological process that, at present, can be partially reproduced only in the mouse.
View Article and Find Full Text PDFPolylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice.
ACS Nano
January 2025
Department of Urology, Peking University First Hospital, Beijing 100034, China.
Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the reproductive toxicity of PLA in male mice and its potential mechanisms. To this end, our in vivo and in vitro experiments demonstrated that after degradation in the digestive system, a significant number of PLA-MP-derived nanoparticles could penetrate the blood-testis barrier (BTB) and localize within the spermatogenic microenvironment.
View Article and Find Full Text PDFPrimary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive lymphoma with molecular heterogeneity not well characterize. In this study, we performed next-generation sequencing analysis for a large number of DNA and RNA samples from patients with PT-DLBCL. DNA sequencing analysis identified ≥ 3 chromosomes with copy number variations (CNVs) and microsatellite instability as prognostic biomarkers, rather than mutations and genetic subtypes.
View Article and Find Full Text PDFMobilize the Troops! Military Involvement in the History of Testicular Cancer.
Urology
January 2025
Department of Urology, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:
This review examines the historical evolution of testicular cancer (TCa) treatment, emphasizing the transformative impact of World War II. Prior to the war, cases of more than 50 testicular tumors were exceedingly rare. The mobilization of American troops, especially after the German Blitz, resulted in widespread military health screenings, leading to a surge in incidental TCa diagnoses during the 1940s.
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