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Effectiveness of regorafenib in second-line therapy for advanced hepatocellular carcinoma: A systematic review and meta-analysis.
Medicine (Baltimore)
January 2025
Department of Hepatobiliary Surgery, The Third Central Hospital of Tianjin, Tianjin, China.
Background: In patients with advanced hepatocellular carcinoma (HCC) following sorafenib failure, regorafenib has been used as an initial second-line drug. It is unclear the real efficacy and safety of sorafenib-regorafenib sequential therapy compared to placebo or other treatment (cabozantinib or nivolumab or placebo) in advanced HCC.
Methods: Four electronic databases (PubMed, Embase, Web of Science, and Ovid) were systematically searched for eligible articles from their inception to July, 2024.
Travel medicine training and experience among primary care physicians in Qatar.
PLoS One
January 2025
Department of Public Health and Preventive Medicine, Faculty of Medicine Cairo University, Cairo, Egypt.
Background: Travel medicine (TM) focuses on preventing and managing travel-related issues. Evidence has become more important than expert opinions in the development of TM standards. This study aimed to evaluate the training and experience of TM among Primary Care Physicians (PCPs) in Qatar and their associated factors.
View Article and Find Full Text PDFThe choice of adjuvant radiotherapy in pancreatic cancer patients after up-front radical surgery.
PLoS One
January 2025
Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Background: The role of adjuvant radiotherapy in pancreatic cancer following radical surgery remains a subject of of controversy. This study aimed to more accurately screen pancreatic patients who benefit from adjuvant radiotherapy.
Methods: Clinicopathologic characteristics of patients with resectable pancreatic cancer were collected from the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015).
Carbon stock quantification and climate mitigation potential of a tropical moist forest in Ethiopia.
PLoS One
January 2025
Cooperative Agricultural Research Center, College of Agriculture, Food and Natural Resources, Prairie View A&M University, Prairie View, TX, United States of America.
The significance of forests in absorbing and storing carbon plays a crucial role in international greenhouse gas policies outlined by the United Nations Framework Convention for Climate Change (UNFCC). This study was conducted in a typical tropical moist forest of Ethiopia to assess its carbon stock, a critical issue in climate policy. The study domain was divided into six strata using elevation criteria.
View Article and Find Full Text PDFAnesthesia Trauma Guidelines: A Systematic Review of Global Accessibility and Quality.
Anesth Analg
January 2025
From the Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado.
This systematic review describes the available clinical practice guidelines (CPGs) for the anesthetic management of trauma and appraises the accessibility and quality of these resources. This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted across 8 databases (MEDLINE, Embase, Web of Science, CABI Digital Library, Global Index Medicus, SciELO, Google Scholar, and National Institute for Health and Care Excellence) for guidelines from 2010 to 2023.
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