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Facile preparation of bifunctional monolayers through diazonium grafting and "click" postfunctionalization: A first step towards efficient aptasensing interfaces.
Bioelectrochemistry
January 2025
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, National University of Science and Technology Politehnica Bucharest, 1-7 Gheorghe Polizu St., 011061 Bucharest, Romania. Electronic address:
Herein, we present an efficient approach for developing electrochemical aptasensing interfaces, by "click" postfunctionalization of phenylethynyl-grafted glassy carbon substrates with mixed monolayers containing biorecognition elements and phosphorylcholine zwitterionic groups. Typically, controlling the composition of multicomponent surface layers by grafting from a mixture of aryldiazonium salts is challenging due to differences in their chemical reactivity. Our approach circumvents this issue by employing the electrochemical reduction of a single aryldiazonium salt containing a silyl-protected alkyne group followed by deprotection, to create phenylethynyl monolayers which can subsequently accommodate the concurrent immobilization of bioreceptors and zwitterionic groups through "click" postfunctionalization.
View Article and Find Full Text PDFInvestigating gender dynamics in forensic toxicology: The role of masculinity and femininity in alcohol and drug abuse.
Adv Clin Exp Med
January 2025
Institute of Human Anatomy, Department of Neurosciences, University of Padova, Italy.
The concept of "gender" refers to the socially constructed characteristics that define feminine or masculine behavior, which are constantly changing and can influence access to healthcare and patterns of help-seeking. These factors significantly impact forensic toxicology, a key area within the medicolegal landscape, forcing the adoption of a gender-sensitive approach to better understand the differing impacts of substances on men and women. Research indicates significant disparities in drug use between genders; men are more likely to abuse alcohol and illicit drugs, while women tend to use prescription medications.
View Article and Find Full Text PDFBackground And Objective: Lipedema is a commonly underdiagnosed chronic condition. This study aimed to evaluate liposuction techniques for lipedema by conducting a systematic review and presenting our experience. A case series study and a comprehensive review were conducted.
View Article and Find Full Text PDFImmunomodulatory properties of extracellular vesicles containing the Spike protein of SARS-CoV-2.
Front Parasitol
April 2024
INRS- Centre Armand-Frappier Santé Biotechnologie, Université du Québec, Laval, QC, Canada.
Extracellular vesicles released by the protozoan parasite display immunomodulatory properties towards mammalian immune cells. In this study, we have evaluated the potential of extracellular vesicles derived from the non-pathogenic protozoan towards the development of a vaccine adjuvant. As a proof of concept, we expressed in a codon-optimized SARS-CoV-2 Spike protein fused to the secreted acid phosphatase signal peptide in the N-terminal and to a 6×-His stretch in the C-terminal.
View Article and Find Full Text PDFGlobal infectious disease early warning models: An updated review and lessons from the COVID-19 pandemic.
Infect Dis Model
June 2025
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Beijing, 100191, China.
An early warning model for infectious diseases is a crucial tool for timely monitoring, prevention, and control of disease outbreaks. The integration of diverse multi-source data using big data and artificial intelligence techniques has emerged as a key approach in advancing these early warning models. This paper presents a comprehensive review of widely utilized early warning models for infectious diseases around the globe.
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