Pretreatment with the neuroleptics, haloperidol and molindone, significantly antagonized the dopamine-induced depressor response in the anaesthetized dogs. The depressor response to dopamine was however, not significantly affected by propranolol, atropine or antazoline pretreatment. The results suggest that molindone like haloperidol, is capable of blocking the vascular dopamine receptors responsible for mediating dopamine-induced vasodilatation in the coeliac, mesenteric and renal vascular bed and fall in blood pressure.
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Article Synopsis
- Adrenomedullin (ADM) is a neuropeptide that regulates blood pressure and vasodilation, particularly in females, but its effect on baroreflex afferent function is not well understood.
- In a study with female rats, microinjection of ADM into the nodose ganglion led to a concentration-dependent reduction in blood pressure and varied responses in different neuron types, highlighting the differential effects on myelinated and unmyelinated neurons.
- The findings suggest that ADM plays a critical role in mediating baroreflex responses related to hypotension and vasodilation, emphasizing the importance of gender differences in these processes.
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