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Real-world clinical features and survival outcomes in diffuse large B-cell lymphoma patients with hepatitis B virus infection.
Infect Agent Cancer
October 2024
Department of Hematology, West China Hospital, Sichuan University, Guo Xue Xiang #37, Chengdu, 610041, Sichuan, China.
Objective: Hepatitis B virus (HBV) infection is associated with the incidence and prognosis of diffuse large B-cell lymphoma (DLBCL), and previous studies differ in terms of clinical characteristics and prognostic factors. In this study, we explored the clinical features and prognostic characteristics of real-world DLBCL patients infected with HBV.
Methods: Patients with pathologically diagnosed primary DLBCL at West China Hospital of Sichuan University were enrolled.
CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1.
JHEP Rep
October 2024
University of Strasbourg, Inserm, Institute for Translational Medicine and Liver Disease (ITM), UMR_S1110, Strasbourg, France.
Article Synopsis
- Chronic HBV infection leads to severe liver disease and liver cancer, and new antiviral treatments like Capsid Assembly Modulators (CAMs) are needed but not fully understood in their mechanism of action.
- Recent research demonstrates that CAM-A compounds reduce HBsAg levels and cause cell death in HBV-infected cells by promoting the aggregation of HBV core proteins (HBc) in the nucleus, triggering apoptosis.
- Discovering that CAM-A facilitates HBc aggregation and activates apoptosis provides insights for developing new therapies aimed at effectively managing chronic HBV infections.
Performance evaluation of the MAGLUMI Hepatitis B virus surface antigen chemiluminescence immunoassay.
J Med Virol
July 2024
Research & Development Department, Shenzhen New Industries Biomedical Engineering Co. Ltd., Shenzhen, China.
A highly sensitive and reliable Hepatitis B virus surface antigen (HBsAg) measurement is essential to universal screening, timely diagnosis, and management of Hepatitis B virus (HBV) infection. This study aimed to evaluate the performance of MAGLUMI HBsAg chemiluminescence immunoassay (CLIA). MAGLUMI HBsAg (CLIA) was compared against ARCHITECT HBsAg.
View Article and Find Full Text PDFVaried immune responses of HBV-specific B cells in patients undergoing pegylated interferon-alpha treatment for chronic hepatitis B.
J Hepatol
December 2024
Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China; Department of Hepatology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian Province, China. Electronic address:
Background & Aims: The changes in HBV-specific B cells in patients with chronic hepatitis B (CHB) undergoing pegylated interferon-α (PEG-IFNα) treatment and achieving functional cure remain unclear. We aimed to evaluate the alterations in HBV-specific B cells during treatment and therefore explored the mechanism of functional recovery of HBsAg-specific B cells.
Methods: We included 39 nucleos(t)ide analogue-treated patients with CHB who received sequential combination therapy with PEG-IFNα and eight treatment-naïve patients.
Coexistence of liver abscess, hepatic cystic echinococcosis and hepatocellular carcinoma: A case report.
World J Clin Cases
May 2024
Department of Interventional Therapy, The Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China.
Article Synopsis
- Human cystic echinococcosis (CE) is a serious zoonotic disease, and its rare coexistence with hepatocellular carcinoma (HCC) and liver abscess is not previously documented.
- A case involving a 65-year-old herdsman revealed the presence of jaundice, elevated alpha fetoprotein levels, and distinct lesions in the liver diagnosed as CE and HCC, along with a subsequent liver abscess.
- This case emphasizes the importance of personalized treatment approaches and multidisciplinary discussions for managing complex interactions between CE, HCC, and liver abscess in patients.
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