AI Article Synopsis
- Insulin binding sites on rat hepatocyte plasma membranes increase significantly within 24-48 hours after 70% liver removal, while glucagon binding sites decrease over 2-8 days.
- The insulin/glucagon binding ratio rises notably, indicating an increased sensitivity to insulin relative to glucagon during liver regeneration.
- Despite the increased insulin binding sites, the activity of glucokinase, an enzyme linked to insulin, is surprisingly reduced during this period, presenting a paradox in liver metabolism.
Article Abstract
During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962606 | PMC |
| http://dx.doi.org/10.1055/s-2007-1014896 | DOI Listing |
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