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The Antifungal Effects of Berberine and Its Proposed Mechanism of Action Through CYP51 Inhibition, as Predicted by Molecular Docking and Binding Analysis.
Molecules
October 2024
School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China.
Fungal infections present a significant health risk, particularly in immunocompromised individuals. Berberine, a natural isoquinoline alkaloid, has demonstrated broad-spectrum antimicrobial activity, though its antifungal potential and underlying mechanisms against both yeast-like and filamentous fungi are not fully understood. This study investigates the antifungal efficacy of berberine against , , , and in vitro, as well as its therapeutic potential in a murine model of cryptococcal infection.
View Article and Find Full Text PDFPropiconazole resistance phenotypes in from South Carolina peaches are linked to point mutations in gene.
Plant Dis
October 2024
Clemson University, Entomology, Soils, and Plant Sciences, 120 Long Hall, Clemson, South Carolina, United States, 29634-0315;
Geotrichum candidum Link (1809) is a yeast-like fungus that causes sour rot of peach (Prunus persica). Outbreaks of the disease have occurred since 2021 in peach fruit kept in cold storage despite post-harvest treatments with propiconazole at a commercial farm in South Carolina (SC). A total of 58 isolates, 40 from symptomatic fruit from cold storage in Saluda County (SC packing house isolates), 11 from three SC orchards in Saluda County, Spartanburg County, and Pickens County (SC non-packing house isolates), and 7 California (CA) isolates (at least 3 from packing houses) were evaluated for propiconazole sensitivity.
View Article and Find Full Text PDFFludioxonil does not antagonize propiconazole activity against .
Plant Dis
October 2024
Clemson University, Entomology, Soils, and Plant Sciences, 120 Long Hall, Clemson, South Carolina, United States, 29634-0315;
Fludioxonil and propiconazole are frequently used fungicides for managing fungal diseases in specialty crops. They are often used in mixture to manage brown rot caused by Monilinia fructicola and sour rot caused by the yeast-like fungus Geotrichum candidum,respectively, on stone fruits. Research indicated, however, that fludioxonil can increase the expression of the ATP-binding cassette transporters CDR1 and CDR2 in the yeast Candida albicans, leading to increased resistance to DMI fungicides.
View Article and Find Full Text PDFHigh Prevalence of Azole-Resistant Aspergillus fumigatus Among Iranian Cystic Fibrosis Patients: Should We Be Concerned?
Mycoses
September 2024
Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at san Antonio, San Antonio, Texas, USA.
Article Synopsis
- - The study investigates the prevalence of azole-resistant Aspergillus fumigatus (ARAf) in Iranian cystic fibrosis (CF) patients, noting that although common fungal infections include Candida species, ARAf poses a significant risk for severe lung infections.
- - Researchers collected and analyzed 120 sputum samples from 103 CF patients, finding that 84.2% were positive for filamentous fungi, with the majority being Aspergillus species and a smaller percentage being Candida species.
- - Among the Aspergillus isolates, 46.5% belonged to the Fumigati section, and 14 showed resistance to azole antifungals, indicating a 9% prevalence of ARAf in the total fungal
Identification of Yeast and Yeast-Like Fungi at a Tertiary Care Center: A Retrospective Study.
Cureus
June 2024
Microbiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Background Fungal infections pose a significant global health challenge. Despite their substantial impact, these ubiquitous fungi can become pathogenic but have not received adequate attention in public health, leading to infections that are often underestimated by the general public and healthcare professionals. species and species play a key role in these infections, with emerging multidrug resistance in species posing considerable challenges.
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