A patient with two histologically different primary pulmonary malignancies occurring simultaneously ten months after a successful cadaveric renal transplantation is reported. One tumor was an adenocarcinoma of the left lung and the other an oat cell carcinoma of the right lung. The differentiation of the two tumors was made by a fluorescein-conjugated antikeratin antibody staining technique. No tumor was present at the time of transplantation as judged from chest examinations. Ten months after transplantation a left-sided pleural effusion caused by the adenocarcinoma occurred simultaneously with a small infiltrate in the apex of the right lung. Simultaneous development of two histologically different lung tumors is unusual, and even more rare after renal transplantation.
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