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The Macklin Effect Following Trauma: A Case Report of Concurrent Pneumothorax, Pneumoperitoneum, Pneumomediastinum, and Pneumoretroperitoneum in an Intubated Young Adult.
Cureus
December 2024
Department of Trauma Surgery, King Saud Medical City, Riyadh, SAU.
Article Synopsis
- Pneumomediastinum, often occurring silently post-trauma, complicates diagnoses especially when paired with other conditions like pneumothorax and pneumoperitoneum, largely due to the Macklin effect where air escapes from ruptured alveoli.
- An 18-year-old male involved in a car crash was found with severe pneumothorax and subcutaneous emphysema but showed no signs of significant esophageal or bronchial injury upon further evaluation.
- Despite alarming initial imaging, the patient's treatment was conservative, allowing for a gradual healing process and eventual discharge without complications, illustrating the need for careful assessment in trauma management.
Hypoxia-guided treatment planning for lung cancer with dose painting by numbers.
J Appl Clin Med Phys
December 2024
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Tumor hypoxia significantly impacts the efficacy of radiotherapy. Recent developments in the technique of dose painting by numbers (DPBN) promise to improve the tumor control probability (TCP) in conventional radiotherapy for hypoxic cancer. The study initially combined the DPBN method with hypoxia-guided dose distribution optimization to overcome hypoxia for lung cancers and evaluated the effectiveness and appropriateness for clinical use of the DPBN plans.
View Article and Find Full Text PDFCoinheritance of Hypertrophic and Arrhythmogenic Cardiomyopathy Variants in a Patient With Hypertrophic Cardiomyopathy.
JACC Case Rep
November 2024
SingHealth Duke-NUS Genomic Medicine Centre, Duke NUS Medical School, Singapore.
Hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC) are phenotypically distinct inherited cardiac diseases. This case report presents a woman aged 51 years with coinheritance of pathogenic/likely pathogenic variants of the β-myosin heavy chain ( p.Glu924Lys) and plakophilin 2 ( p.
View Article and Find Full Text PDFA Novel Description of Medial Meniscus Vascularization: A Multicenter Study Introducing the "Medial Meniscal Artery".
Am J Sports Med
December 2024
Division of Sports Medicine, Midwest Orthopaedics at Rush, Chicago, Illinois, USA.
Background: The microvasculature of the human meniscus has been previously described by Arnoczky and Warren. However, to date, the qualitative and quantitative extra-articular vascular anatomy of the medial meniscus has not been characterized.
Purposes: To perform a qualitative and quantitative anatomic study of the extra-articular medial meniscal vasculature and to introduce the novel "medial meniscal artery" (MMA), potentially providing future guidelines for the treatment of meniscal abnormalities.
There is growing evidence for the impact of arts engagement on later life cognition. However, confounding by socioeconomic factors may have led to an overestimation of this association. We analyzed data from 4,344 older adults in the Wisconsin Longitudinal Study.
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