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Therapeutic potential of cannabidiol polypharmacology in neuropsychiatric disorders.
Trends Pharmacol Sci
January 2025
Dept. Science, Roma Tre University, Rome, Italy; Neuroendocrinology, Metabolism and Neuropharmacology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy. Electronic address:
Cannabidiol (CBD), the primary non-intoxicating compound in cannabis, is currently approved for treating rare, treatment-resistant seizures. Recent preclinical research suggests that CBD's multifaceted mechanisms of action in the brain, which involve multiple molecular targets, underlie its neuroprotective, anti-inflammatory, anxiolytic, and antipsychotic effects. Clinical trials are also exploring CBD's therapeutic potential beyond its current uses.
View Article and Find Full Text PDFCannabidiol abrogates cue-induced anxiety associated with normalization of mitochondria-specific transcripts and linoleic acid in the nucleus accumbens shell.
Mol Psychiatry
January 2025
Icahn School of Medicine at Mount Sinai, Departments of Neuroscience, Psychiatry; Addiction Institute of Mount Sinai, New York, NY, USA.
Anxiety disorders are one of the top contributors to psychiatric burden worldwide. Recent years have seen a dramatic rise in the potential anxiolytic properties ascribed to cannabidiol (CBD), a non-intoxicating constituent of the Cannabis Sativa plant. This has led to several clinical trials underway to examine the therapeutic potential of CBD for anxiety disorders.
View Article and Find Full Text PDFEvent-level differences in quantity, frequency, and consequences of cannabis use by modes of use: Moderation by differences in how often individuals use each mode among sexual minority women and gender diverse individuals.
J Stud Alcohol Drugs
January 2025
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine.
Background: A handful of studies have examined differences in the subjective effects and consequences of utilizing different modes of cannabis (e.g., smoking vs.
View Article and Find Full Text PDFMarijuana Poisoning in Canines in the Aburrá Valley (Antioquia-Colombia), 2023-2024.
Vet Med Int
January 2025
Group of Veterinary Investigation GIVET, Program of Veterinary Medicine, Lasallian University Corporation, Bogotá, Colombia.
Marijuana poisoning in canines is still considered a taboo topic. Poisoning in pets is becoming increasingly common, in many cases resulting in severe clinical signs, such as ataxia, urinary incontinence, mydriasis, depression, and hyperesthesia. Colombia does not have any reliable test for the diagnosis of exposure to cannabis in animals, and it is not an obligation to report this kind of poisoning to the authorities.
View Article and Find Full Text PDFEvaluating Delta-8-THC-Induced Psychosis: A Systematic Review.
Clin Neuropharmacol
January 2025
Eastern Virginia Medical School, Norfolk, VA.
Objectives: This study reviews literature on the psychiatric effects of delta-8-THC, particularly psychosis and severe mental health outcomes, to highlight the need for further research and regulation.
Background: Marijuana, the most widely used illicit drug in the United States, sees increasing use due to legalization. Although moderate use is generally safe, adverse effects can occur, especially in those with preexisting conditions.
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