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Regulatory problems and developmental psychopathology within the first 2 years of living-a nested in cohort population-based study.
Front Child Adolesc Psychiatry
February 2024
National Institute of Public Health, Faculty of Health Sciences, University of Southern Denmark, Copenhagen, Denmark.
Background: Infancy regulatory problems (RP) of sleep, feeding and eating, and excessive crying are thought to play a key role in the development of psychopathology in childhood, but knowledge of the early trajectories is limited.
Objective: To explore RP at ages 8-11 months and the associations with mental health problems at 1½ years, and assess the influences of maternal mental health problems and relationship problems.
Methods: RP was explored in a nested in-cohort sample ( = 416) drawn from a community-based cohort ( = 2,973).
Community health nurses' concerns about infant regulatory problems are predictive of mental disorders diagnosed at hospital: a prospective cohort study.
Front Child Adolesc Psychiatry
January 2024
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Introduction: Regulatory problems of eating, sleeping, and crying in infancy may index mental health vulnerability in older ages, and knowledge is needed to inform strategies to break the developmental trajectories of dysregulation in early childhood. In this study, we examined the prospective associations between infant regulatory problems at the age of 8-10 months identified by community health nurses (CHN) and mental disorders diagnosed in hospital settings in children aged 1-8 years.
Methods: From a cohort of all newborn children in 15 municipalities in the Capital Region of Copenhagen ( = 43,922) we included all children who were examined by CHNs at the scheduled home visit at the age of 8-10 months ( = 36,338).
Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats.
J Neuroendocrinol
December 2024
Douglas Mental Health University Institute Research Center, Montreal, Quebec, Canada.
Being raised under adverse conditions during infancy and childhood represents a significant risk factor for developing later psychopathologies and dysfunctions in emotional, affective, and cognitive abilities. Depending on the type, timing, and duration of early adversity, different consequences emerge across the sexes in both human and animal models, although our understanding of the underlying interactions between sex and early life stress (ELS) is still incomplete. In this study, we used the limited bedding (LB) paradigm, a well-described model of ELS in rat pups during the first 10 days of life, and tested whether masculinization of the female brain by neonatal injections of estradiol benzoate (EB) would recapitulate the ELS-induced vulnerability phenotype of males on morphology of the basolateral amygdala (BLA) principal neurons and pre-adolescent and adult behavior.
View Article and Find Full Text PDFDo meaningful dimensions of childhood adversity exist? Data-driven evidence from two prospective cohort studies.
J Child Psychol Psychiatry
December 2024
Department of Experimental Psychology, Medical Sciences Division, University of Oxford, Oxford, UK.
Background: There is not yet a consensus on the best way to conceptualise adverse childhood experiences (ACEs). We used data-driven methods across two populations to examine (a) if there were meaningful dimensions underlying ACEs and (b) whether dimensions were differentially associated with increased risk of adolescent psychopathology.
Methods: Participants were 18,539 British children from the UK Millennium Cohort Study (MCS) and 11,876 American children from the US Adolescent Brain Cognitive Development Study (ABCD).
Parental Sensitivity and Infant Social Withdrawal During Mother-Infant and Father-Infant Interactions.
Infancy
December 2024
Center for Family Studies, University Institute of Psychotherapy, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
While social withdrawal is a normal defense mechanism displayed by infants to regulate interactions, it can negatively impact infant development when it becomes chronic, leading to delays in motor, cognitive, and communication difficulties in later development. Infant withdrawal was associated with low levels of parental sensitivity (i.e.
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