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Acute intrathecal administration of quipazine elicits air-stepping behavior.
Behav Pharmacol
June 2021
Department of Psychology, Idaho State University, Meridian, Idaho, USA.
Serotonin plays a pivotal role in the initiation and modulation of locomotor behavior in the intact animal, as well as following spinal cord injury. Quipazine, a serotonin 2 receptor agonist, has been used successfully to initiate and restore motor behavior in rodents. Although evidence suggests that the effects of quipazine are spinally mediated, it is unclear whether intrathecal (IT) quipazine administration alone is enough to activate locomotor-like activity or whether additional stimulation is needed.
View Article and Find Full Text PDFThe functional link between tail-pinch-induced food intake and emotionality and its possible role in stress coping in rats.
J Physiol Sci
November 2018
Department of Brain Science and Engineering, Kyushu Institute of Technology, Kitakyushu, Fukuoka, Japan.
Tail pinch facilitates eating in rats. We investigated an unidentified link between tail-pinch-induced eating behavior and individual emotionality in male Sprague-Dawley rats. Anxiety-like behavior was assessed on the elevated plus maze (EPM) and in the open field test (OFT).
View Article and Find Full Text PDFCell discharge correlates of posterior hypothalamic theta rhythm recorded in anesthetized rats and brain slices.
Hippocampus
October 2016
Department of Neurobiology, the University of Łódź, Pomorska Str. No 141/143, Łódź, 91-236, Poland.
Kowalczyk et al. (Hippocampus 2014; 24:7-20) were probably the first to conduct a systemic study of posterior hypothalamic area (PHa) theta rhythm in anesthetized rats. They demonstrated that local PHa theta field potentials were tail-pinch resistant and could be generated in urethane-anesthetized rats independently of ongoing hippocampal formation theta rhythm.
View Article and Find Full Text PDFBrief fear preexposure facilitates subsequent fear conditioning.
Neurosci Res
June 2015
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan; Center for Information and Neural Networks, Suita City, Osaka 565-0835, Japan. Electronic address:
Post-traumatic stress disorder (PTSD) is an anxiety disorder that occurs following an unexpected exposure to a severe psychological event. A history of a brief trauma is reported to affect a risk for future PTSD development; however, little is known about the mechanisms by which a previous trauma exposure drives the sensitivity to a late-coming trauma. Using a mouse PTSD model, we found that a prior foot shock enhances contextual fear conditioning.
View Article and Find Full Text PDFAntinociceptive activity of CC44, a biotinylated improgan congener.
Eur J Pharmacol
August 2013
Center for Neuropharmacology and Neuroscience, Albany Medical College MC-136, 47 New Scotland Avenue, Albany, NY 12208, USA.
Improgan, a non-opioid, antinociceptive drug, activates descending analgesic circuits following brain administration, but the improgan receptor remains unidentified. Since biotinylation of drugs can enhance drug potency or facilitate discovery of new drug targets, a biotinylated congener of improgan (CC44) and several related compounds were synthesized and tested for antinociceptive activity. In rats and mice, intracerebroventricular (i.
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