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Comprehensive craniometry for sagittal synostosis.
Neurosurg Focus
January 2025
6Plastic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.
Objective: Sagittal synostosis is the most common type of craniosynostosis, resulting in deformity with distinctive morphological characteristics. These include occipital narrowing, parietal narrowing, anteriorly shifted vertex with parietal depression, and exaggerated frontal bossing. The traditional cephalic index affords limited reliability in quantifying initial severity and correction.
View Article and Find Full Text PDFApplication of OSA-VET and qualiquantitative tear tests in brachycephalic dogs with and without keratoconjunctivitis sicca.
Vet Res Commun
November 2024
Department of Veterinary Surgery, Federal University of Paraná (UFPR), Palotina, Brazil.
The aim was to compare the outcomes acquired from the OSA-Vet device with conventional quantitative and qualitative tear tests and between groups within each test, in brachycephalic dogs both healthy and those diagnosed with keratoconjunctivitis sicca. The dogs were divided into four groups: healthy dogs (HD), with mild KCS (MIKCS); moderate KCS (MOKCS); severe KCS (SKCS). All patients underwent ocular surface diagnostic examination in the following order, with a 10-minute interval between tests: non-invasive tear film breakup time (TBUTNI - OSA-Vet), tear meniscus height (TMH-OSA-Vet), meniscometry (I-Tear test), Schirmer Tear Test-1 (STT-1), and tear film breakup time (TBUT).
View Article and Find Full Text PDFCranial bone microarchitecture in a mouse model for syndromic craniosynostosis.
J Anat
December 2024
UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Crouzon syndrome is a congenital craniofacial disorder caused by mutations in the Fibroblast Growth Factor Receptor 2 (FGFR2). It is characterized by the premature fusion of cranial sutures, leading to a brachycephalic head shape, and midfacial hypoplasia. The aim of this study was to investigate the effect of the FGFR2 mutation on the microarchitecture of cranial bones at different stages of postnatal skull development, using the FGFR2 mouse model.
View Article and Find Full Text PDFGeometric growth of the normal human craniocervical junction from 0 to 18 years old.
J Anat
December 2024
Craniofacial Growth and Form, Hôpital Necker - Enfants Malades, Assistance Publique - Hôpitaux de Paris, Paris, France.
The craniocervical junction (CCJ) forms the bridge between the skull and the spine, a highly mobile group of joints that allows the mobility of the head in every direction. The CCJ plays a major role in protecting the inferior brainstem (bulb) and spinal cord, therefore also requiring some stability. Children are subjected to multiple constitutive or acquired diseases involving the CCJ: primary bone diseases such as in FGFR-related craniosynostoses or acquired conditions such as congenital torticollis, cervical spine luxation, and neurological disorders.
View Article and Find Full Text PDFBrain MRI segmentation of Zika-Exposed normocephalic infants shows smaller amygdala volumes.
PLoS One
July 2023
Department of Radiology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
Background: Infants with congenital Zika syndrome (CZS) are known to exhibit characteristic brain abnormalities. However, the brain anatomy of Zika virus (ZIKV)-exposed infants, born to ZIKV-positive pregnant mothers, who have normal-appearing head characteristics at birth, has not been evaluated in detail. The aim of this prospective study is, therefore, to compare the cortical and subcortical brain structural volume measures of ZIKV-exposed normocephalic infants to age-matched healthy controls.
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