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As a valuable medicine and food homology plant suitable for people of all ages, has been used for dietary nourishment and medicinal purposes with high acceptance for a long history. Interest in the potential anticancer functions of has increased due to its numerous chemical constituents with diverse structures and extensive pharmacological activities. With the growing interest, -based antitumor traditional Chinese medicine (TCM) formulations are also considered as vital intervention strategy for cancer, which exhibit prospective antitumor potential with multiple targets, multiple signaling pathways, and less side effects in both experimental and epidemiological studies.
View Article and Find Full Text PDFShensiqigui tablets alleviate bleomycin-induced pulmonary fibrosis by inhibiting the hedgehog/wnt-β-catenin pathway.
Histol Histopathol
February 2025
Pharmaceutical Sciences Research Division, Department of Pharmacy, Medical Supplies Center, Chinese PLA General Hospital, Beijing, PR China.
Background: Pulmonary fibrosis (PF) is a refractory disease characterized by inflammation and fibrosis. Shensiqigui Tablets (SSQGT), a combination of Codonopsis pilosula, Astragalus, and Angelica, is a traditional Chinese medicine with anti-inflammatory and antioxidant properties. Therefore, SSQGT may be a potential therapeutic agent for managing PF.
View Article and Find Full Text PDFCombining network pharmacology and molecular docking to explore the pharmacological mechanism of Codonopsis Radix.-Hedysarum Multijugum Maxim.-Atractylodes Macrocephala Koidz. in treating lung cancer.
BMC Complement Med Ther
February 2025
Department of Cardiothoracic Surgery, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No.136, Jingzhou Street, Xiangyang, Hubei, 441021, People's Republic of China.
Aim: To explore the potential mechanism of the treatment of lung cancer (LC) with Codonopsis Radix.-Hedysarum Multijugum Maxim.-Atractylodes Macrocephala Koidz.
View Article and Find Full Text PDFManshenkang granules alleviate fibrosis in chronic renal failure rats by regulating the PDE4b/cAMP pathway.
J Ethnopharmacol
February 2025
Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, 410011, China; Hunan Provincial Engineering Research Central of Translational Medical and Innovative Drug, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. Electronic address:
Ethnopharmacological Relevance: Manshenkang granules (MSKG) is a traditional Chinese medicinal formula used to treat chronic renal failure, comprising Rheum tanguticum Maxim. ex Balf., Salvia miltiorrhiza Bunge, Citrus × aurantium L.
View Article and Find Full Text PDFExploring the mechanism of action of Lobetyolin in the treatment of allergic rhinitis based on network pharmacology and molecular docking.
Medicine (Baltimore)
February 2025
Department of Otolaryngology, Head and Neck Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, P. R. China.
Lobetyolin (LBT) is an important active ingredient in the traditional medicinal plant Codonopsis pilosula (Franch.) Nannf. However, the pharmacological targets and mechanisms of action of LBT against allergic rhinitis (AR) are not known.
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