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Buprenorphine and postpartum contraception utilization among people with opioid use disorder: a multi-state analysis.
Addict Sci Clin Pract
January 2025
Departments of Family and Community Medicine and Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.
Background: The postpartum period provides an opportunity for birthing people with opioid use disorder (OUD) to consider their future reproductive health goals. However, the relationship between the use of medication for opioid use disorder (MOUD) and contraception utilization is not well understood. We used multistate administrative claims data to compare contraception utilization rates among postpartum people with OUD initiating buprenorphine (BUP) versus no medication (psychosocial services receipt without MOUD (PSY)) in the United States (US).
View Article and Find Full Text PDFThe role of macroautophagy in substance use disorders.
Ann N Y Acad Sci
December 2024
Department of Medicine, School of Basic Medicine, Ningbo University, Ningbo, China.
Macroautophagy, a universal cellular process, sends cellular material to lysosomes for breakdown and is often activated by stressors like hypoxia or drug exposure. It is vital for protein balance, neurotransmitter release, synaptic function, and neuron survival. The role of macroautophagy in substance use disorders is dual.
View Article and Find Full Text PDFNeuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats.
Transl Psychiatry
December 2024
Center for Substance Abuse Research, Temple University, Philadelphia, PA, USA.
Recent progress in psychiatric research has highlighted neuroinflammation in the pathophysiology of opioid use disorder (OUD), suggesting that heightened immune responses in the brain may exacerbate opioid-related mechanisms. However, the molecular mechanisms resulting from neuroinflammation that impact opioid-induced behaviors and transcriptional pathways remain poorly understood. In this study, we have begun to address this critical knowledge gap by exploring the intersection between neuroinflammation and exposure to the opioid heroin, utilizing lipopolysaccharide (LPS)-induced neuroinflammation, to investigate transcriptional changes in the nucleus accumbens (NAc), an essential region in the mesolimbic dopamine system that mediates opioid reward.
View Article and Find Full Text PDFHarm reduction and its monitoring in Europe, from EMCDDA to EUDA.
Harm Reduct J
December 2024
EUDA, Praça Europa 1, Cais do Sodré, 1249-289, Lisbon, Portugal.
Background: Harm Reduction, conceptualized by Russell Newcombe in the late 1980s, has revolutionized how drug use, individuals who use drugs, and drug policies are understood globally. Emerging from the HIV/AIDS crisis, Harm Reduction sought to address the dire rates of drug-related infections and the overwhelming burden on healthcare providers. Early initiatives, such as Opioid Substitution Treatment (OST) and needle exchange programs, were met with resistance but gradually established new standards of care, transforming attitudes toward people who use drugs and prioritizing human-centered, rather than solely medical, approaches.
View Article and Find Full Text PDFSinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway.
BMC Gastroenterol
December 2024
Department of Gastroenterology, the First Affiliated Hospital of Bengbu Medical University, No. 287, Changhuai Road, Bengbu, Anhui, 233000, China.
Article Synopsis
- The study investigated the effects of sinomenine hydrochloride (SH) on colitis induced by DSS in mice, focusing on the Notch signaling pathway.
- Mice were divided into four groups and assessed for disease activity, mucosal injury, and histopathological changes, revealing that SH significantly alleviated colitis symptoms and reduced inflammation markers.
- Results indicated that SH treatment lowered the expression of key proteins in the Notch signaling pathway and reduced pro-inflammatory cytokines, suggesting that its therapeutic effect is linked to inhibiting Notch pathway overactivation.
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