In continuation of previous reports, it was found that the neurotrophic factor (NF) of the central nervous system of the cat for the maintenance of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7; AcChoEase) in the denervated cat superior cervical ganglion is a heat-stable compound of low molecular weight (less than 1,000) and that it is probably a peptide. Acetylcholine and nerve growth factor were eliminated as the NF; cyclic AMP produced an effect similar to that of the NF. The NF is probably not present in significant amounts in liver or skeletal muscle; it appears to be present in small intestine. It does not modify the AcChoEase content of the nondenervated cat superior cervical ganglion. Possible mechanisms of action of the NF are discussed.
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| http://dx.doi.org/10.1073/pnas.81.20.6539 | DOI Listing |
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