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Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway.
Microb Biotechnol
January 2025
Huadong Medical Institute of Biotechniques, Nanjing, China.
Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear.
View Article and Find Full Text PDFEffect of growth dynamics on the structural, photophysical and pseudocapacitance properties of famatinite copper antimony sulphide colloidal nanostructures (including nanosheets).
Dalton Trans
January 2025
Department of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T State University, 2907 East Gate City Boulevard, Greensboro, NC 27401, USA.
Facile phase selective synthesis of copper antimony sulphide (CAS) nanostructures is important because of their tunable photoconductive and electrochemical properties. In this study, off-stoichiometric famatinite phase CAS (CAS) quasi-spherical and quasi-hexagonal colloidal nanostructures (including nanosheets) of sizes, 2.4-18.
View Article and Find Full Text PDFTranscriptome sequencing reveals jasmonate playing a key role in ALA-induced osmotic stress tolerance in strawberry.
BMC Plant Biol
January 2025
College of Horticulture, Nanjing Agricultural University, Nanjing, 211800, China.
Background: Strawberry (Fragaria × annanasa Duch.) is an important economic fruit worldwide, whose growth and development are often hindered by water deficiency. 5-Aminolevulinic acid (ALA), a natural plant growth regulator, has been suggested to mitigate the osmotic damages by promoting root water absorption, osmotic adjustment, photosynthetic capacity, and antioxidant improvement.
View Article and Find Full Text PDFPLGA-Nano-Encapsulated Disulfiram Inhibits Cancer Stem Cells and Targets Non-Small Cell Lung Cancer In Vitro and In Vivo.
Biomolecules
December 2024
Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Cancer stem cells (CSCs) play a key role in non-small cell lung cancer (NSCLC) chemoresistance and metastasis. In this study, we used two NSCLC cell lines to investigate the regulating effect of hypoxia in the induction and maintenance of CSC traits. Our study demonstrated hypoxia-induced stemness and chemoresistance at levels comparable to those in typical CSC sphere culture.
View Article and Find Full Text PDFPossible role of superoxide dismutase 3 in hypoxia-induced developmental defects in murine molars.
J Oral Biosci
December 2024
Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan.
Objectives: To investigate the effects of hypoxia on tooth germ development in mice and explore the underlying mechanisms.
Methods: Tooth germs were extracted from E14.5 mouse embryos and divided into the control and hypoxia groups for organ culture.
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