AI Article Synopsis
- AKR mice are extensively studied for spontaneous hemoblastoses in oncology and hematology, with 500 mice used in this research.
- 400 mice were monitored throughout their lives, and 10 were sacrificed monthly for detailed autopsy and cytological examinations.
- Findings indicate that the hemoblastoses observed are generalized forms of lymphosarcoma, displaying notable cytochemical and cytological diversity.
Article Abstract
Spontaneous hemoblastoses of AKR mice are widely used in experimental oncology and hematology. To study their morphological characteristics, 500 AKR mice were used. Of these, 400 animals were followed up throughout their lives. Ten animals were sacrificed monthly out of the group of 100 rats. All the animals which died or were sacrificed were autopsied and subjected to cytological and histological studies. Besides, 36 animals with hemoblastoses were examined cytochemically for the activity of acid and alkaline phosphatases, peroxidase and nonspecific esterase and glycogen. Analysis of the data obtained suggests that hemoblastoses of AKR mice are the generalized forms of lymphosarcoma, characterized by a significant degree of cytochemical and cytological heterogeneity.
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View Article and Find Full Text PDFArticle Synopsis
- AKR mice are extensively studied for spontaneous hemoblastoses in oncology and hematology, with 500 mice used in this research.
- 400 mice were monitored throughout their lives, and 10 were sacrificed monthly for detailed autopsy and cytological examinations.
- Findings indicate that the hemoblastoses observed are generalized forms of lymphosarcoma, displaying notable cytochemical and cytological diversity.
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