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Methylation status of selected genes in non-small cell lung carcinoma - current knowledge and future perspectives.
Neoplasma
December 2024
Department of Clinical and Molecular Pathology and Medical Genetics, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.
DNA methylation is recognized as an early event in cancer initiation and progression. This review aimed to compare the methylation status of promoter regions in selected genes across different histological subtypes of non-small cell lung cancer (NSCLC), including adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and the rare but highly aggressive large-cell neuroendocrine carcinoma (LCNEC). A comprehensive literature search was conducted in the PubMed database until August 17, 2024, using standardized keywords to identify reports on promoter methylation in NSCLC.
View Article and Find Full Text PDFEstimating Trends in Cardiovascular Disease Risk for the EXPOSE (Explaining Population Trends in Cardiovascular Risk: A Comparative Analysis of Health Transitions in South Africa and England) Study: Repeated Cross-Sectional Study.
JMIR Cardio
January 2025
Faculty of Education, Health and Human Sciences, University of Greenwich, London, United Kingdom.
Background: Cardiovascular diseases (CVDs) are the leading cause of death globally. Demographic, behavioral, socioeconomic, health care, and psychosocial variables considered risk factors for CVD are routinely measured in population health surveys, providing opportunities to examine health transitions. Studying the drivers of health transitions in countries where multiple burdens of disease persist (eg, South Africa), compared with countries regarded as models of "epidemiologic transition" (eg, England), can provide knowledge on where best to intervene and direct resources to reduce the disease burden.
View Article and Find Full Text PDFThe American Heart Association's (AHA) Life's Essential 8 (LE8) metrics provide a framework for assessing cardiovascular health (CVH). This study evaluates the relationship between CVH levels from LE8 and mortality risk, considering biological aging's role. Using data from the NHANES non-CVD adult population, CVH scores were categorized as low (< 50), moderate (50-79), and high (≥ 80) per AHA guidelines.
View Article and Find Full Text PDFHow Do Nurses Decide on Missed Nursing Care? A Grounded Theory Study of Grassroots Arrangement of Nursing Care.
J Clin Nurs
January 2025
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Aims: To explore the complete decision-making process and action logic of nurses making autonomous decisions that result in missed nursing care.
Background: The complex characteristics of patients in Intensive Care Units place higher demands on the allocation of nursing resources, as well as on the professional skills, resilience and ethics of nursing staff. Preventing missed nursing care is particularly crucial in Intensive Care Units.
Prevalence and Contributors of Postpartum Fatigue in Chinese Primiparous Women: A Cross-Sectional Study.
Br J Hosp Med (Lond)
December 2024
Obstetrics Department, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Jiangsu, China.
The prevalence of postpartum fatigue among primipara is high in China, which seriously affects women's subsequent physical and mental recovery. In order to deeply understand this phenomenon, domestic scholars began to conduct research on postpartum fatigue from the aspects of assessment tools and intervention measures. This study aims to investigate postpartum fatigue in primiparous women and its association with family functioning and social support, providing valuable insights for improving the condition in this population.
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