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Insights into Anton Syndrome: When the brain denies blindness.

J Clin Neurosci

February 2024

Department of Neurosurgery, Neurosurgery Clinic, Birgunj, Nepal. Electronic address:

Introduction: Anosognosia, a neurological condition, involves a lack of awareness of one's neurological or psychiatric deficits. Anton Syndrome (AS), an unusual form of anosognosia, manifests as bilateral vision loss coupled with denial of blindness. This systematic review delves into 64 studies encompassing 72 AS cases to explore demographics, clinical presentations, treatments, and outcomes.

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Article Synopsis
  • Bilateral infarcts in the posterior cerebral arteries can cause visual and memory issues, highlighting the importance of the occipital lobe and inferior longitudinal fasciculus in cognitive functions.
  • In 1902, Dide and Botcazo linked various deficits (like visual field issues and memory loss) to specific brain lesions, coining the term Dide-Botcazo syndrome, which saw a revival in the 1980s along with the inclusion of Anton's syndrome.
  • The historical review suggests using Dide-Botcazo syndrome to describe a type of vascular dementia where visual and memory impairments occur together, acknowledging its relevance despite modern advances in understanding memory neurobiology.
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Dide-Botcazo syndrome is a rare clinical syndrome characterized by a combination of cortical blindness with anosognosia for blindness, amnesia and topographical disorientation, secondary to bilateral occipital cortex lesions also involving the infero-medial temporal lobe structure. We report a case of a man who acutely presented confusion and cortical blindness. The cerebral angiography demonstrated bilateral occlusion of posterior cerebral artery (PCA).

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Dide-Botcazo syndrome (Rev Neurol, 1902) is a unique neuropsychological syndrome, characterized by combinations of cortical blindness, amnesia, and topographical disorientation. We report 82-year-old right-handed man manifesting such syndrome associated with Anton's syndrome after a cardioembolic infarction in the distribution of the bilateral posterior cerebral arteries. The MRI study demonstrated recent extensive infarctions bilaterally in the occipital lobes and the medial temporal lobes, and thalamus.

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A patient is described who, following a post-eclamptic intravascular disseminated coagulation, had a bilateral stroke in the territories supplied by the posterior cerebral arteries. She showed an anosognosia of her cortical blindness associated with a severe recent memory loss.

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