Idiopathic juvenile retinoschisis is a sex-linked disease, which generally involves the macula and the retinal periphery in 50% of cases. The authors report a case of juvenile retinoschisis in which the central schisis was associated with wide non-perfused retinal areas causing the growth of retinal and epipapillary neovascularizations in one eye. The new vessels produced an intravitreal hemorrhage. The arising of non-perfused retinal areas is probably determined by capillary insufficiency secondary to the alteration of its vascular trophism due to the retinal detachment. This may cause a break of the blood-retinal barrier with subsequent capillary occlusions. We performed laser photocoagulation of the non-perfused areas, and complete regression of the neovascularization was obtained.
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J Clin Med
January 2025
Department of Ophthalmology, Boston Children's Hospital, Boston, MA 02115, USA.
Pediatric macular disorders are a diverse group of inherited retinal diseases characterized by central vision loss due to dysfunction and degeneration of the macula, the region of the retina responsible for high-acuity vision. Common disorders in this category include Stargardt disease, Best vitelliform macular dystrophy, and X-linked retinoschisis. These conditions often manifest during childhood or adolescence, with symptoms such as progressive central vision loss, photophobia, and difficulty with fine visual tasks.
View Article and Find Full Text PDFOphthalmic Surg Lasers Imaging Retina
January 2025
Tractional retinoschisis (TRS) secondary to proliferative diabetic retinopathy (PDR) may be differentiated from tractional retinal detachment (TRD) by its characteristically nonprogressive course. The purpose of the current study was to describe the use of swept-source optical coherence tomography angiography (SS-OCTA) in the diagnosis and monitoring of TRS secondary to PDR. Retrospective, consecutive case series of patients with TRS secondary to PDR are featured.
View Article and Find Full Text PDFRetin Cases Brief Rep
January 2025
School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Purpose: This study examines the multimodal imaging (MMI) findings in two cases of unilateral Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis (SNIFR), including detailed findings from the unaffected fellow eye.
Methods: Macular spectral domain optical coherence tomography (OCT) and 3x3 mm optical coherence tomography angiography (OCTA), microperimetry, full-field electroretinography (ff-ERG) for both the affected and the fellow eye were reviewed.
Results: The MMI findings were consistent across the two cases (71-year-old female and 60-year-old female).
Taiwan J Ophthalmol
November 2024
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
This study investigates the occurrence of multiple parafoveal retinal detachments (RDs) in myopic traction maculopathy (MTM), emphasizing the atypical extrafoveal involvement compared to central foveal detachment commonly observed. Patient 1, a 46-year-old male, exhibited MTM with retinoschisis and four small subretinal fluid (SRF) pockets inferior to the fovea, accompanied by a hyperautofluorescent vitelliform deposit. Patient 2, a 43-year-old male, reported ring-shaped dim vision in the left eye, displaying MTM with six stable SRF pockets surrounding the fovea.
View Article and Find Full Text PDFGenes (Basel)
December 2024
Department of Ophthalmology, Eye Center, UC Davis School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Background/objective: The Rs1 exon-1-del rat (Rs1KO) XLRS model shows normal retinal development until postnatal day 12 (P12) when small cystic spaces start to form in the inner nuclear layer. These spaces enlarge rapidly, peak at P15, and then collapse by P19.
Methods: We explored the possible involvement of Kir4.
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