Electrically induced afterdischarge (ADs) were evoked in the cats' dorsal hippocampus. The action of the conditioning prestimulation of the pallidus nucleus on AD duration was studied. A significant facilitatory influence was observed when pallidal conditioning stimulation immediately preceded hippocampal test stimulation. The time course of the phenomenon showed a decrease of the conditioning action when the interval between the two stimulations increased : complete disappearance of the effect occurred after about 800 ms. Results are discussed as far as functional relationships between basal ganglia and rhinencephalic system are concerned.
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Alzheimers Dement
December 2024
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Introduction: Progressive supranuclear palsy (PSP) is a devastating 4R tauopathy affecting motor functions and is often misdiagnosed/underdiagnosed due to a lack of specific biomarkers. Synaptic loss is an eminent feature of tauopathies including PSP. Novel synaptic positron emission tomography tracer UCB-J holds great potential for early diagnosis; however, there is a substantial knowledge gap in terms of the mechanism and the extent and nature of synaptic loss in PSP.
View Article and Find Full Text PDFNeuromodulation
December 2023
Center for Bioethics, Harvard Medical School, Boston, MA, USA. Electronic address:
Introduction: Childhood dystonia is often nonresponsive to medications, and refractory cases are increasingly being treated with deep brain stimulation (DBS). However, many have noted that there is little consensus about when DBS should be offered, and there has been little examination of clinicians' decision-making process when determining whether to offer DBS for childhood dystonia.
Objectives: This study aimed to identify and examine the factors considered by pediatric movement disorder specialists before offering DBS.
Front Neuroanat
July 2011
Division of System Neurophysiology, National Institute for Physiological Sciences Okazaki, Japan.
Somatotopic organization is a fundamental and key concept to understand how the cortico-basal ganglia loop works. It is also indispensable knowledge to perform stereotaxic surgery for movement disorders. Here I would like to describe the somatotopic organization of the basal ganglia, which consist of the striatum, subthalamic nucleus, globus pallidus, and substantia nigra.
View Article and Find Full Text PDFGlobus sensation is a medially felt lump in the throat. It can be associated with a number of different diseases, but this symptom may also occur monosymptomatically as a somatoform disorder or as a secondary somatoform illness behavior. Globus sensation may be persistent or intermittent.
View Article and Find Full Text PDFBrain Nerve
December 2009
Division of System Neurophysiology, National Institute for Physiological Science, 38 Nishigo-naka, Myodaiji, Okazaki, Aichi 444-8585, Japan.
Somatotopy is a fundamental concept that is essential for the understanding of the functions of the brain. Here, I have described somatotopy in the basal ganglia that comprise the striatum, subthalamic nucleus, globus pallidus, and substantia nigra. Projections from the motor cortical subregions that represent different body parts terminate in different regions of these nuclei.
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