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Phenotypic, genotypic and proteomic variations between poor and robust colonizing Campylobacter jejuni strains.
Microb Pathog
August 2024
Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration (US FDA), Jefferson, AR, 72079, USA.
Campylobacter jejuni is one of the major causes of bacterial gastrointestinal disease in humans worldwide. This foodborne pathogen colonizes the intestinal tracts of chickens, and consumption of chicken and poultry products is identified as a common route of transmission. We analyzed two C.
View Article and Find Full Text PDFTransgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance.
Poult Sci
December 2023
Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742 USA. Electronic address:
Marek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental factors. Further investigation of the host-virus interaction mechanisms that impact MD resistance is needed to achieve greater MD control.
View Article and Find Full Text PDFContribution of the TCRβ Repertoire to Marek's Disease Genetic Resistance in the Chicken.
Viruses
February 2023
Avian Disease and Oncology Laboratory, US National Poultry Research Center, Agricultural Research Service, USDA, East Lansing, MI 48823, USA.
Marek's disease (MD) is a lymphoproliferative disease of chickens induced by Marek's disease virus (MDV), an oncogenic α-herpesvirus. MDV has increased in virulence, prompting continued efforts in both improved vaccines and enhanced genetic resistance. Model pairs of genetically MD-resistant and MD-susceptible chickens that were either MHC-matched or MHC-congenic allowed characterization of T cell receptor (TCR) repertoires associated with MDV infection.
View Article and Find Full Text PDFComprehensive molecular characterization of complete mitogenome assemblies of 33 Eimeria isolates infecting domestic chickens.
Parasit Vectors
March 2023
Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Sichuan, 611130, China.
Background: Coccidiosis caused by Eimeria is one of the most severe chicken diseases and poses a great economic threat to the poultry industry. Understanding the evolutionary biology of chicken Eimeria parasites underpins development of new interactions toward the improved prevention and control of this poultry disease.
Methods: We presented an evolutionary blueprint of chicken coccidia by genetically characterizing complete mitogenome assemblies of 33 isolates representing all seven known Eimeria species infecting chickens in China.
The Role of Dendritic Cells in the Host Response to Marek's Disease Virus (MDV) as Shown by Transcriptomic Analysis of Susceptible and Resistant Birds.
Pathogens
November 2022
The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Despite the successful control of highly contagious tumorigenic Marek's disease (MD) by vaccination, a continuous increase in MD virus (MDV) virulence over recent decades has put emphasis on the development of more MD-resistant chickens. The cell types and genes involved in resistance therefore need to be recognized. The virus is primarily lymphotropic, but research should also focus on innate immunity, as innate immune cells are among the first to encounter MDV.
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