AI Article Synopsis
- Mast cells were identified in the synovial membranes of patients with osteoarthritis and rheumatoid arthritis using a new staining method that highlights specific interactions in the cells.
- In patients with rheumatoid arthritis, the number of mast cells in the subsynovial layer was significantly lower compared to those with osteoarthritis, potentially due to distinct tissue changes in rheumatoid cases.
- Overall mast cell counts between rheumatoid and osteoarthritis patients showed no significant differences when not considering their specific distribution patterns in the tissue layers.
Article Abstract
Mast cells are demonstrated in synovial membranes of patients with osteo-arthritis and rheumatoid arthritis using a new staining principle based on interaction of heparin in mast cell granules with peroxidase labeled avidin. It was found that mast cell numbers in the subsynovial layer of patients with rheumatoid arthritis were significantly lower than those in patients suffering from osteo-arthritis. This decrease can be mainly attributed to patients with rheumatoid arthritis whose synovitis was characterized by a distinct histomorphological pattern consisting of lining cell ulcers and granulation tissue. However, when mast cell numbers in rheumatoid arthritis and osteo-arthritis patients were compared without respect to mast cell distribution in the subsynovial layer or the stratum fibrosum, no statistical differences between the diseases could be observed.
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