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Epg5 links proteotoxic stress due to defective autophagic clearance and epileptogenesis in and Vici syndrome patients.
Autophagy
February 2025
Department of Basic and Clinical Neuroscience, King's College London, London, United Kingdom.
Epilepsy is a common neurological condition that arises from dysfunctional neuronal circuit control due to either acquired or innate disorders. Autophagy is an essential neuronal housekeeping mechanism, which causes severe proteotoxic stress when impaired. Autophagy impairment has been associated to epileptogenesis through a variety of molecular mechanisms.
View Article and Find Full Text PDFOCRL1 Deficiency Affects the Intracellular Traffic of ApoER2 and Impairs Reelin-Induced Responses.
Biomolecules
July 2024
Laboratorio de Tráfico Intracelular y Señalización, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 7810128, Chile.
Lowe Syndrome (LS) is a rare X-linked disorder characterized by renal dysfunction, cataracts, and several central nervous system (CNS) anomalies. The mechanisms underlying the neurological dysfunction in LS remain unclear, albeit they share some phenotypic characteristics similar to the deficiency or dysfunction of the Reelin signaling, a relevant pathway with roles in CNS development and neuronal functions. In this study, we investigated the role of OCRL1, an inositol polyphosphate 5-phosphatase encoded by the gene, mutated in LS, focusing on its impact on endosomal trafficking and receptor recycling in human neuronal cells.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a new prognostic model to estimate the risk of pulmonary complications after elective surgery, which is the leading cause of post-surgery death.
- Data from a large international cohort of over 86,000 patients was used, applying machine learning techniques to identify risk factors for complications like pneumonia and respiratory distress.
- The model, named the GSU-Pulmonary Score, was validated with additional cohorts and is available as an online tool to assist in patient care and resource management, especially important during pandemic recovery.
Perceived barriers and influencing factors of psychological help-seeking amongst Chinese nurses exposed to COVID-19.
J Res Nurs
May 2024
Research Student, School of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.
Background: The COVID-19 pandemic has caused psychological problems among nurses worldwide. However, their willingness to seek professional help is relatively low, due to perceived barriers that have remained unknown.
Aims: This study analysed the potential barriers and influencing factors of psychological help-seeking among nurses participating in community COVID-19 epidemic prevention work.
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