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DIAGNOSTIC AND CLINICAL ASPECTS OF NORMOCALCEMIC PARATHYROID HYPERPLASIA AND NON-RENAL SECONDARY HYPERPARATHYROIDISM IN EXPOSED AND NON;EXPOSED TO IONIZING RADIATION INDIVIDUALS (LITERATURE REVIEW AND OWN RESEARCH DATA).
Probl Radiac Med Radiobiol
December 2024
State Institution «National Research Center for Radiation Medicine, Hematology and Oncology of the National Academy of Medical Sciences of Ukraine», 53 Yuriya Illienka Street, Kyiv, 04050, Ukraine.
Parathyroids are the key regulators of calcium-phosphorus metabolism. By means of parathyroid hormone they respond to any changes in the serum level of calcium and phosphorus ions and determine the integrity of skeleton, affecting almost all systems and cells where calcium and phosphorus are involved in metabolism and/or signaling.Disorders of parathyroid function are associated with significant complications accompanying secondary hyperparathyroidism.
View Article and Find Full Text PDFLetter to Editor from McCarroll et al: "Approach to the Patient: Normocalcemic Primary Hyperparathyroidism".
J Clin Endocrinol Metab
December 2024
Mater Misericordiae University Hospital, Dublin, Ireland.
Bone Mineral Density and First Line Imaging with [F]fluorocholine PET/CT in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism: Results from a Single Center.
Diagnostics (Basel)
November 2024
Department of Nuclear Medicine and Endocrinology, University Hospital Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria.
: Primary hyperparathyroidism (PHPT) is associated with normal or elevated calcium levels and affects bone mineral density. The proportion of cases predisposed to metabolic bone disease is unknown in patients with PHPT. The aim of this study was to assess bone mineral density and bone quality in patients with normo- or hypercalcemic primary hyperparathyroidism undergoing baseline parathyroid gland assessment with [F]fluorocholine PET/CT imaging.
View Article and Find Full Text PDFInfluence of normocalcemic primary hyperparathyroidism in bone density alterations of the jaws in patients with periodontitis.
Med Oral Patol Oral Cir Bucal
January 2025
University of Valencia, c/Gascó Oliag nº1 Valencia, ZIP:46010, Spain
Article Synopsis
- Normocalcemic Primary Hyperparathyroidism (NPHPT) leads to excess secretion of parathyroid hormone (PTH), increasing bone resorption and potentially affecting periodontal health due to shared pathological mechanisms.* -
- A study involving 86 NPHPT patients and 87 controls evaluated bone density and periodontal status, revealing that NPHPT patients had a higher incidence of severe periodontitis compared to the control group.* -
- The findings suggested a significant relationship between NPHPT and periodontitis, with NPHPT patients having 1.78 times greater odds of developing periodontitis, linked to increased PTH levels and decreased vitamin D affecting bone density.*
Persistent elevated serum parathyroid hormone levels with normocalcaemia after parathyroidectomy: Secondary hyperparathyroidism or pseudo- hyperparathyroidism?
Cir Esp (Engl Ed)
November 2024
Servicio Cirugía General y Digestiva, Hospital Universitario de Gran Canaria Dr. Negrín, Spain.
Article Synopsis
- The study examined how long it takes for parathyroid hormone (PTH) levels to return to normal after parathyroid surgery for primary hyperparathyroidism, evaluating data from 186 patients over five years.
- Out of the final group of 176 patients, 26.1% had elevated PTH levels post-surgery despite normal calcium levels, with a median time to normalization of 6 months.
- Findings suggest that high preoperative PTH levels can predict postoperative normocalcaemic hyperparathyroidism, while vitamin D and creatinine levels don’t appear to impact the normalization timeline.
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