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Isolation of Antiplasmodial Oxazoles and Isoflavonoids from the Roots of and Total Synthesis of Oxazole-type Alkaloids.
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January 2025
Department of Chemical and Biological engineering, School of Engineering and Technology, National University of Mongolia, Ulaanbaatar 14201, Mongolia.
A chemical examination of a root extract of led to the isolation and identification of 23 compounds, including oxazole-type alkaloids and isoflavonoid derivatives. Notably, three oxazole-type alkaloids (, , and ) and two isoflavonoid derivatives ( and ) were obtained from a natural source for the first time. In addition, derived 2,5-diphenyloxazoles and their derivatives were synthesized.
View Article and Find Full Text PDFAkkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway.
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Huadong Medical Institute of Biotechniques, Nanjing, China.
Acetaminophen induced acute liver injury (ALI) has a high incidence and is a serious medical problem, but there is a lack of effective treatment. The enterohepatic axis is one of the targets of recent attention due to its important role in liver diseases. Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear.
View Article and Find Full Text PDFEffect of Ph on the Physicochemical Properties of a Cassava Peel Starch Biopolymer.
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Carrera de Agroindustria, Escuela Superior Politécnica Agropecuaria de Manabí Manuel Félix López, ESPAM-MFL, Calceta. 130250, Ecuador.
Background/aims: This study investigates how pH levels affect the characteristics of biopolymer films manufactured from cassava peel starch. Cassava peel starch's abundance and biodegradability make it a promising candidate for sustainable packaging. The study seeks to improve film qualities such as thickness, density, moisture content, solubility, and optical properties by altering pH levels.
View Article and Find Full Text PDFAOPs to connect food additives' effects on gut microbiota to health outcomes.
ALTEX
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Laboratory of Hepato-Gastroenterology, Institute of Experimental and Clinical Research, UCLouvain, Brussels, Belgium.
The gut microbiota is unanimously acknowledged as playing a central role in human health, notably through the production of various metabolites, including short-chain fatty acids, secondary bile acids, vitamins or neurotransmitters. Beyond contributing to gut health itself, these microbial metabolites significantly impact multiple organ systems by participating in key signaling pathways along the well documented gut-organ axes. Chemicals ingested through food might interact with our gut microbiota, altering metabolites production with consequences on health.
View Article and Find Full Text PDFFrom Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker.
Angew Chem Int Ed Engl
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Guizhou University, State Key Laboratory of Green Pesticide, Center for Research and Development of Fine Chemicals, Huaxi, 550025, Guiyang, CHINA.
Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defenses and obstruct the ingress of agrochemicals. Even when agrochemicals disintegrate biofilms, splashing and bouncing during application disperse active ingredients away from target sites.
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