The amino acid and sugar compositions as well as long N-terminal sequences and the C-terminal amino acids of the two subunits of carp gonadotropin, SU I and SU II, were determined. An important homology was demonstrated between SU I and alpha-subunits and between SU II and beta-subunits of mammalian gonadotropins. Moreover SU II was more closely related to the beta-subunit of LH than to the beta-subunit of FSH.
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http://dx.doi.org/10.1016/s0300-9084(78)80704-4 | DOI Listing |
Int J Mol Sci
February 2025
State Key Laboratory of Mariculture Bioreading and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
The Chinese tongue sole () is a marine flatfish of significant economic value, characterized by pronounced female-biased sexual size dimorphism (SSD). Sexual differences of cell number and gene expression within the PIT-1 lineage of the pituitary gland may be crucial for interpreting the female-biased SSD of . Among hormones secreted by PIT-1 cell lineage, growth hormone (), prolactin (), prolactin 2 (), and somatolactin () comprise a gene family within the extensive superfamily of class-1 helical cytokines.
View Article and Find Full Text PDFEndocrinology
February 2025
Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, FHU 1000 days for health, EGID, DistALZ, UMR_S112, Lille, France.
Gonadotropin-releasing hormone (GnRH) is traditionally recognized as the central regulator of reproduction through its pulsatile secretion, which governs the hypothalamic-pituitary-gonadal (HPG) axis. However, recent evidence has highlighted its broader role in brain development and function, including in cognitive and higher intellectual processes. GnRH production follows distinct phases, from its early activation during minipuberty - the first postnatal activation of GnRH neurons during the infantile period, its reactivation and stabilization starting at puberty, and its eventual decline with age and the loss of gonadal steroid feedback.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
College of Pharmacy, University of Illinois, Chicago, IL 60612, USA.
Overexpression of the gonadotropin-releasing hormone receptor (GnRH-R) plays a vital role in the advancement of reproductive malignancies such as ovarian, endometrial, and prostate cancer. Peptidomimetic GnRH antagonists are a substantial therapeutic development, providing fast and reversible suppression of gonadotropins by directly blocking GnRH-R. Unlike typical GnRH agonists, these antagonists prevent the early hormonal flare, have a faster onset of action, and have a lower risk of cardiovascular problems.
View Article and Find Full Text PDFInt J Gynaecol Obstet
January 2025
Department of Surgical Gynecology, Hanoi Obstetrics and Gynecology Hospital, Hanoi, Vietnam.
Retroperitoneal ectopic pregnancy is an uncommon condition in clinical practice, often associated with misdiagnosis and unconventional treatment. Delayed interventions can lead to poor prognosis and sometimes catastrophic situations. Due to the limited number of reported cases in the literature, an established treatment protocol has yet to be introduced.
View Article and Find Full Text PDFPostgrad Med J
December 2024
Department of Obstetrics and Gynecology, Vienna University Hospital/Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Background: On the second day of my clinical observership in the Obgyn Department of the Vienna University Hospital, I saw a suspected case of caesarean scar pregnancy on follow-up, with one of my very senior professors, in the gynaecology outpatient clinic.
Methods: The 29-year-old multigravida with a previous caesarean section had earlier presented to the emergency room with vaginal bleeding at 7 weeks of gestation.
Results: Ultrasound scan revealed a non-viable low-lying gestational sac located near the caesarean section scar, with a myometrial thickness of 0.
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