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Effects of Different Concentrations of AmB on the Unsaturated Phospholipid-Cholesterol Membrane Using the Langmuir Monolayer and Liposome Models.
Molecules
November 2024
Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, School of Electronic Information, Xijing University, Xi'an 710123, China.
Article Synopsis
- Amphotericin B (AmB) causes toxicity to red blood cell membranes, leading to hemolysis and limiting its effective use in treating invasive fungal infections.
- The study investigated how different concentrations of AmB (5, 45, 85, and 125 μg/mL) interact with unsaturated phospholipid membranes containing cholesterol, using methods like the Langmuir model and fluorescence techniques.
- Findings revealed that as AmB concentration increases, it not only alters the organization and elasticity of the membrane but also affects the balance between hydrophobic and hydrophilic domains, particularly when concentrations exceed 85 μg/mL.
Changes in free energy barrier for water permeation by stretch-induced phase transitions in phospholipid/cholesterol bilayers.
J Biomol Struct Dyn
October 2024
Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Water permeation through phospholipid/cholesterol bilayers is the key to understanding tension-induced rupture of biological cell membranes. We performed molecular dynamics simulations of stretched phospholipid/cholesterol bilayers to investigate changes in the free energy profile of water molecules across the bilayer and the lipid structure responsible for water permeation. We modeled stretching of the bilayer by applying areal strain.
View Article and Find Full Text PDFEffect of Trastuzumab on the thermodynamic behavior and roughness of fluid membrane using unsaturated phospholipid/cholesterol mixed monolayer model.
Arch Biochem Biophys
July 2023
Xi'an Key Laboratory of Human-Machine Integration and Control Technology for Intelligent Rehabilitation School of Computer Science, Xijing University, Xi'an, 710123, PR China. Electronic address:
The microenvironment near the receptor on biological membrane plays an important role in regulating drug-receptor interaction, and the interaction between drugs and lipids on membrane can also affect the microenvironment of membrane, which may affect drugs' efficacy or cause the drug resistance. Trastuzumab (Tmab) is a monoclonal antibody, used to treat early breast cancer associated with the overexpression of Human Epidermal growth factor Receptor 2 (HER2). But its effectiveness is limited due to its tendency to make tumor cells resistant to the drug.
View Article and Find Full Text PDFInteraction of Phospholipid, Cholesterol, Beta-Carotene, and Vitamin C Molecules in Liposome-Based Drug Delivery Systems: An Study.
Adv Pharmacol Pharm Sci
January 2023
Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, BSD Campus, Tangerang 15345, Indonesia.
This paper investigates the interaction within a liposome-based drug delivery system . Results confirmed that phospholipids, cholesterol, beta-carotene, and vitamin C in the liposome structures interact noncovalently. The formation of noncovalent interactions indicates that the liposomal structures from phospholipid molecules will not result in chemical changes to the drug or any molecules encapsulated within.
View Article and Find Full Text PDFThe concentration-dependent effect of hydrocortisone on the structure of model lung surfactant monolayer by using an approach.
RSC Adv
November 2022
School of Mechanical and Mechatronic Engineering, University of Technology Sydney 15 Broadway Ultimo 2007 NSW Australia
Understanding the adsorption mechanism of corticosteroids in the lung surfactant requires the knowledge of corticosteroid molecular interactions with lung surfactant monolayer (LSM). We employed coarse-grained molecular dynamics simulation to explore the action of hydrocortisone on an LSM comprised of a phospholipid, cholesterol and surfactant protein. The structural and dynamical morphology of the lung surfactant monolayer at different surface tensions were investigated to assess the monolayer compressibility.
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