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Outcomes following long-term disease control with immune checkpoint inhibitors in patients with advanced melanoma.
Eur J Cancer
January 2025
Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW, Australia; Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address:
Immune checkpoint inhibitors (ICI) can achieve durable responses in patients with advanced melanoma, and results from clinical trials suggest cure may be possible for a subset of patients. Despite clinical trial data, little is known about the risk, character, and clinical outcome of late recurrences after ICI. This study aimed to explore the disease outcomes and survival in a cohort of patients with long-term responses to ICI.
View Article and Find Full Text PDFIntroduction: Prostatic hyperplasia (BPH) is one of the most common diseases of elderly and senile men. Its natural "evolution" leads to an increase in deformity disorders, gradual decompensation of the bladder and the progression of CKD. If the morphogenesis of BPH, as well as the patterns of adaptive and pathological restructuring of the lower urinary tract are described in the literature, then there is practically no evidence of adaptive processes in the prostate itself against the background of the growth of hyperplasia nodes.
View Article and Find Full Text PDFMolecular insights on the origin and development of waxy genotypes in major crop plants.
Brief Funct Genomics
May 2024
Washington University, St. Louis, MO 63130-4899.
Article Synopsis
- Starch is an important component of seeds, with waxy varieties (high amylopectin, low amylose) being key for both cultural significance and industrial uses.
- The waxy trait is controlled by a single gene (GBSSI), which has different variants that affect amylose levels in various crops.
- Advances in breeding techniques and research on waxy alleles are paving the way for the development of tailored crops with specific starch properties to meet rising demand.
Molecular functions of microRNAs in colorectal cancer: recent roles in proliferation, angiogenesis, apoptosis, and chemoresistance.
Naunyn Schmiedebergs Arch Pharmacol
August 2024
Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.
Article Synopsis
- - MiRNAs are small non-coding RNA molecules that regulate gene expression by binding to mRNA, leading to its degradation or repression, with their biogenesis involving several detailed steps such as transcription and processing.
- - Colorectal cancer, a common and serious disease with low early diagnosis rates and high metastasis, is influenced by genetic and epigenetic factors, especially miRNAs, which can act as tumor suppressors or oncogenes depending on their target genes.
- - MiRNAs show promise as biomarkers for colorectal cancer due to their stability and ease of detection in body fluids, enabling differentiation between cancer patients and healthy individuals, predicting cancer stage, and monitoring responses to treatment.
Mast Cell: A Mysterious Character in Skin Cancer.
In Vivo
December 2023
Department of Management, Legislation and Communication in Dental Medicine, First Department of Dentistry, Faculty of Dental Medicine, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania.
Cutaneous malignancies represent a real concern and burden for the healthcare system, not only due to their increased frequency, but also due to the significant number of deaths attributed to these types of cancer. The genesis of tumors, their progression and metastasis are highly complex and researched subjects; apparently, mast cells (MCs) constitute an important piece in the complicated jigsaw puzzle of cancer. This article reviews the current knowledge of the roles MCs might play in the development of cutaneous malignancies.
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