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New information on Bonapartenykus (Alvarezsauridae: Theropoda) from the Allen Formation (middle Campanian-lower Maastrichtian) of Río Negro Province, Patagonia, Argentina clarifies the Patagonykinae body plan.
PLoS One
January 2025
School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.
Alvarezsauria is a group of morphologically distinctive, medium- to small-sized later-diverging coelurosaurian theropod dinosaurs, whose record ranges from the Late Jurassic to the Late Cretaceous. This clade had a widespread distribution in Laurasia in what is now Europe, Asia, and North America, although there are also several Cretaceous taxa from Gondwana in what is now Argentina that all belong to the family Alvarezsauridae. Although alvarezsaurid taxonomic diversity and anatomical knowledge has expanded over the last decade, alvarezsaurid internal phylogenetic relationships remain highly debated.
View Article and Find Full Text PDFThe physical activity and sedentary behavior among pregnant women in Macao: A cross-sectional study.
PLoS One
January 2025
Peking University Health Science Center, Macao Polytechnic University Nursing Academy, Macao Polytechnic University, Macao, China.
Objective: The current investigation sought to elucidate the prevalence and contributing factors of sedentary behavior among pregnant women in Macao, a densely populated region characterized by a distinctive fusion of Eastern and Western cultures and a thriving global economy.
Methods: Through a cross-sectional study design, a total of 306 expectant mothers were recruited via various social media platforms and completed a sociodemographic questionnaire alongside the Chinese version of the Pregnancy Physical Activity Questionnaire.
Results: The findings revealed that sedentary activities accounted for a relatively small proportion (7.
Abnormalities in male gametophytes development responsible for low seed set of Peudosasa subsolida.
PLoS One
January 2025
The Key Laboratory of Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of Education, Southwest Forestry University, Yunnan, China.
Pseudosasa subsolida belongs to the Pseudosasa genus within the Poaceae family. Due to its unique flowering cycle and the physiological traits associated with asexual reproduction, acquiring floral material from P. subsolida is particularly challenging.
View Article and Find Full Text PDFOvarian cancer prevention through opportunistic salpingectomy during abdominal surgeries: A cost-effectiveness modeling study.
PLoS Med
January 2025
Department of Gynecology and Reproductive Medicine, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany.
Background: There is indication that the fallopian tubes might be involved in ovarian cancer pathogenesis and their removal reduces cancer risk. Hence, bilateral salpingectomy during hysterectomy or sterilization, so called opportunistic salpingectomy (OS), is gaining wide acceptance as a preventive strategy. Recently, it was discussed whether implementation of OS at other gynecologic surgery, e.
View Article and Find Full Text PDFAccurate Physics-Based Prediction of Binding Affinities of RNA- and DNA-Targeting Ligands.
J Chem Inf Model
January 2025
Schrödinger Incorporated, Cambridge, Massachusetts 02142, United States.
Article Synopsis
- Predicting how well ligands bind to nucleic acids is challenging, which limits the development of small-molecule drugs for diseases like cancer and infections.
- Recent advancements in computational methods, particularly free-energy perturbation (FEP), have improved predictions for protein-ligand binding affinities, but its effectiveness for nucleic acids was unclear.
- This study found that using FEP+ software with the OPLS4 force field can accurately predict binding energies for over 100 ligands interacting with DNA/RNA, achieving predictions that closely match experimental data and could aid drug discovery.
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