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Hepatoprotective effect of methanol fruit extract of L in highly active antiretroviral therapy-induced toxicity in Wistar rats.
Drug Chem Toxicol
March 2024
Department of Science Technical and Vocational Education, Makerere University, Kampala, Uganda.
Article Synopsis
- Prolonged use of Highly Active Antiretroviral Therapy (HAART) can cause liver toxicity, with limited treatment options for hepatic cell regeneration.
- A study assessed the protective effects of Methanol fruit extract (MFEPG) on rats undergoing HAART, revealing that MFEPG helped restore normal liver function and reduced oxidative damage indicators.
- The findings suggest that MFEPG has antioxidant properties capable of mitigating HAART-induced liver injury, but further research is necessary to confirm its safety and efficacy.
Methanol Crude Peel Extract of Prevents Oxidative Damage in Kidneys of Rats Exposed to Highly Active Antiretroviral Therapy.
J Exp Pharmacol
January 2024
Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University-Western Campus, Bushenyi, Uganda.
Background: Highly Active Antiretroviral Therapy (HAART) has been linked to oxidative damage to kidney cells leading to renal disease in people living with HIV/AIDS on HAART treatment. The toxic effects of HAART affect the patients' quality of life leading to poor adherence to their regimen. Therefore, the purpose of this study was to investigate the nephron-protective activity of methanol crude peel extract of (MPEPG) in HAART-administered Wistar rats.
View Article and Find Full Text PDFSuvorexant improves mitochondrial dynamics with the regulation of orexinergic and mTOR activation in rats exhibiting PTSD-like symptoms.
J Affect Disord
April 2024
Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005, U.P., India. Electronic address:
Background: Increasing evidence suggests that mitochondrial dysfunction plays a significant role in PTSD. However, the exact mechanism is still unclear. Mitochondrial dynamics could be one of the mechanisms, as it is crucial for mitochondrial homeostasis and is widely affected in traumatic situations.
View Article and Find Full Text PDFDifferent damaging effects of volatile anaesthetics alone or in combination with 1 and 2 Gy gamma-irradiation on mouse liver DNA: a preliminary study.
Arh Hig Rada Toksikol
March 2023
National Health Service Foundation Trust, Warrington and Halton Teaching Hospitals, Warrington, United Kingdom.
As the number of radiotherapy and radiology diagnostic procedures increases from year to year, so does the use of general volatile anaesthesia (VA). Although considered safe, VA exposure can cause different adverse effects and, in combination with ionising radiation (IR), can also cause synergistic effects. However, little is known about DNA damage incurred by this combination at doses applied in a single radiotherapy treatment.
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