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Leveraging the nanotopography of filamentous fungal chitin-glucan nano/microfibrous spheres (FNS) coated with collagen (type I) for scaffolded fibroblast spheroids in regenerative medicine.
Tissue Cell
January 2025
School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea. Electronic address:
Numerous naturally occurring biological structures have inspired the development of innovative biomaterials for a wide range of applications. Notably, the nanotopographical architectures found in natural materials have been leveraged in biomaterial design to enhance cell adhesion and proliferation and improve tissue regeneration for biomedical applications. In this study, we fabricated three-dimensional (3D) chitin-glucan micro/nanofibrous fungal-based spheres coated with collagen (type I) to mimic the native extracellular matrix (ECM) microenvironment.
View Article and Find Full Text PDFNon-Invasive Prenatal Diagnosis of Chromosomal and Monogenic Disease by a Novel Bioinspired Micro-Nanochip for Isolating Fetal Nucleated Red Blood Cells.
Int J Nanomedicine
December 2024
Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People's Republic of China.
Purpose: Fetal nucleated red blood cells (fNRBCs) in the peripheral blood of pregnant women contain comprehensive fetal genetic information, making them an ideal target for non-invasive prenatal diagnosis (NIPD). However, challenges in identifying, enriching, and detecting fNRBCs limit their diagnostic potential.
Methods: To overcome these obstacles, we developed a novel biomimetic chip, replicating the micro-nano structure of red rose petals on polydimethylsiloxane (PDMS).
Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice.
Cell Death Dis
December 2024
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Sickle cell disease (SCD) is a severe hematological disorder characterized by erythrocyte sickling that causes significant morbidity and mortality. Skeletal complications of SCD include a high incidence of bone loss, especially in vertebrae, leading to fragility fractures that contribute to disease burden. Whether hydroxyurea (HU), a front-line therapy for SCD ameliorates bone disease has not been established.
View Article and Find Full Text PDFSingle cell micro-absorption spectroscopy system with temperature control: System design and spectral analysis.
Rev Sci Instrum
December 2024
Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai 200241, China.
Micro-absorption spectroscopy is a useful tool for studying the biological characteristics of single cells. However, the weak spectral signal, due to low absorption caused by the tiny optical path length of the cell, makes the spectral data noisy and difficult to analyze. This paper describes a device for single-cell microspectroscopy measurement that integrates an optical fiber spectrometer and an image CCD within a microscopic system, allowing for the simultaneous acquisition of morphology information and the absorption spectrum of a single cell.
View Article and Find Full Text PDFLack of genotoxicity of iron oxide maghemite (γ-Fe2O3) and magnetite (Fe3O4) nanoparticles to Oreochromis niloticus after acute exposures.
Genet Mol Biol
September 2024
Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Genética e Morfologia, Brasília, DF, Brazil.
Iron oxide nanoparticles (FeO-NPs) are widely used in scientific and technological fields. Environmental concerns have been raised about residual FeO-NPs levels as their toxicity and bioaccumulative potential are not well understood. Oreochromis niloticus were exposed to nanoparticles of γ-Fe2O3 and Fe3O4.
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