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Modelling pacemaker oscillations in lymphatic muscle cells: lengthened action potentials by two distinct system effects.
R Soc Open Sci
January 2025
School of Mathematics & Statistics, University of Sydney, Sydney, New South Wales 2006, Australia.
Lymphatic system failures contribute to cardiovascular and various other diseases. A critical function of the lymphatic vascular system is the active pumping of fluid from the interstitium back into the blood circulation by periodic contractions of lymphatic muscle cells (LMCs) in the vessel walls. As in cardiac pacemaking, these periodic contractions can be interpreted as occurring due to linked pacemaker oscillations in the LMC membrane potential (M-clock) and calcium concentration (C-clock).
View Article and Find Full Text PDFGallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis.
J Transl Med
January 2025
Department of Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine / Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu, 210029, China.
Background: Skeletal muscle injury caused by excessive exercise is one of the most commonly seen clinical diseases. It is indispensable to explore drugs for treating and relieving skeletal muscle injury. Gallic acid (GA) is a polyphenolic extract that has anti-inflammatory and antioxidant biological activities.
View Article and Find Full Text PDFSplit Membrane: A New Model to Accelerate All-Atom MD Simulation of Phospholipid Bilayers.
J Chem Inf Model
January 2025
CEITEC─Central European Institute of Technology, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
All-atom molecular dynamics simulations are powerful tools for studying cell membranes and their interactions with proteins and other molecules. However, these processes occur on time scales determined by the diffusion rate of phospholipids, which are challenging to achieve in all-atom models. Here, we present a new all-atom model that accelerates lipid diffusion by splitting phospholipid molecules into head and tail groups.
View Article and Find Full Text PDFSimulation Study of Envelope Wave Electrical Nerve Stimulation Based on a Real Head Model.
Neuroinformatics
January 2025
Shanghai Berry Electronic Technology Co., Ltd., Shanghai, 200000, China.
In recent years, the modulation of brain neural activity by applied electromagnetic fields has become a hot spot in neuroscience research. Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are two common non-invasive neuromodulation techniques. However, conventional tACS has limited stimulation effects in the deeper parts of the brain.
View Article and Find Full Text PDFInvestigating the expression profiles of cysteine string proteins (CSPs) in cochlear tissue.
J Otol
October 2024
The Institute of Audiology and Balance Science, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Objective: This study aims to explore the expression patterns of cysteine string protein alpha (CSPα) and cysteine string protein beta (CSPβ) in the mammalian inner ear, with an emphasis on their temporal dynamics during the developmental stages of C57BL/6 mice.
Methods: We utilized immunofluorescence staining to assess the localization and distribution of CSPα and CSPβ within the inner ears of C57BL/6 mice and miniature pigs. Additionally, this method facilitated the investigation of their temporal expression profiles.
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