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Epoetin alfa has a potent anxiolytic effect on naive female rats.
BMC Pharmacol Toxicol
January 2025
Department of Physiology, Ankara University Medicine Faculty, Ankara, Turkey.
Background: Epoetin alfa is a derivative of the erythropoietin hormone. This study aims to investigate the epoetin alfa effect on anxiety-like behaviors.
Methods: Adult female Wistar Albino rats were divided into Control (n = 8), 1000 U Epoetien alfa, and 2000 U Epoetien alpha.
UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer.
J Transl Med
January 2025
Department of Gynecology, The Fourth Hospital of Hebei Medical University, No.12 Jiankang Road, Shijiazhuang, 050000, Hebei, China.
Background: Immune cells within tumor tissues play important roles in remodeling the tumor microenvironment, thus affecting tumor progression and the therapeutic response. The current study was designed to identify key markers of plasma cells and explore their role in high-grade serous ovarian cancer (HGSOC).
Methods: We utilized single-cell sequencing data from the Gene Expression Omnibus (GEO) database to identify key immune cell types within HGSOC tissues and to extract related markers via the Seurat package.
Effect of temperature cycles on the sleep-like state in Hydra vulgaris.
Zoological Lett
January 2025
Faculty of Arts and Science, Kyushu University, Fukuoka, 819-0395, Japan.
Background: Sleep is a conserved physiological phenomenon across species. It is mainly controlled by two processes: a circadian clock that regulates the timing of sleep and a homeostat that regulates the sleep drive. Even cnidarians, such as Hydra and jellyfish, which lack a brain, display sleep-like states.
View Article and Find Full Text PDFHealth-related quality of life associated with fatigue, physical activity and activity pacing in adults with chronic conditions.
BMC Sports Sci Med Rehabil
January 2025
Department of Sport Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK.
Background: Fatigue and inactivity are linked to decreased health-related quality of life (HRQoL) in chronic conditions. A multidimensional approach to activity pacing may improve HRQoL by promoting physical activity (PA) and alleviating fatigue. Addressing fatigue across chronic conditions is crucial, especially when underlying causes are unknown.
View Article and Find Full Text PDFThe moderating effect of psychological capital on the relationship between nurses' perceived workplace bullying and emotional exhaustion: a cross-sectional study.
BMC Nurs
January 2025
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei Province, China.
Background: Workplace bullying (WPB) is common in nursing profession, leading to adverse effects on nurses' health and teamwork. Although it has been suggested that psychological capital (PsyCap) could potentially moderate the relationship between WPB and emotional exhaustion, there is currently a lack of direct empirical evidence supporting this claim. Therefore, this study aims to examine how PsyCap moderates the relationship between WPB and emotional exhaustion in nurses.
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