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Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma.
J Hepatocell Carcinoma
January 2025
Departments of Pharmacology, School of Pharmacy, Qingdao University Medical College, Shandong, People's Republic of China.
Objective: Artesunate can inhibit the proliferation of various tumor cells and has practical value in developing anti-tumor drugs. However, its biological activity against hepatocellular carcinoma is weak. The efficacy of its anti-tumor effect needs to be improved.
View Article and Find Full Text PDFLactoferrin Modulates Radiation Response Under Hypoxic Conditions, Possibly Through the Regulation of ROS Production in a Cell Type-Specific Manner.
Antioxidants (Basel)
December 2024
Department of Radiation Disaster Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
Lactoferrin (LF) is an iron-binding glycoprotein of the transferrin family and has been suggested to have a variety of biological functions, including anticancer activity. However, the effects of LF and its mechanisms in anticancer therapies, especially in radiotherapy against cancer cells under hypoxic conditions, are not well-determined. In this study, we focused on the molecular mechanisms of LF functions in cells under hypoxic conditions.
View Article and Find Full Text PDFElucidation on the Interaction Between Transferrin and Tetrachlorobisphenol A Based on Multispectroscopic Analysis, Molecular Docking Technique, and Conformational Studies.
Luminescence
January 2025
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi, China.
Tetrachlorobisphenol A (TCBPA) is a kind of fire retardant extensively used in our life, but it can accumulate in organisms and potentially have toxic effects. Transferrin (TF) is a glycoprotein predominantly present in the blood plasma, serving as an essential mediator for the transportation of iron and other small molecules. In our study, various techniques including multi-spectroscopic and molecular docking were employed to examine the interaction between TCBPA and TF.
View Article and Find Full Text PDFComparative analysis of the structure and content of N-glycans from different commercial whey protein materials.
J Food Sci
January 2025
College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin, China.
Infant formulas are constantly being updated and upgraded, and N-glycans are functional glycans that have not been fully exploited to date. Commercial whey protein materials are often used as basic ingredients in infant formulas. Therefore, it is important to study N-glycans in commercial whey protein materials.
View Article and Find Full Text PDFLocal erythropoiesis directs oxygen availability in bone fracture repair.
bioRxiv
January 2025
Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Bone fracture ruptures blood vessels and disrupts the bone marrow, the site of new red blood cell production (erythropoiesis). Current dogma holds that bone fracture causes severe hypoxia at the fracture site, due to vascular rupture, and that this hypoxia must be overcome for regeneration. Here, we show that the early fracture site is not hypoxic, but instead exhibits high oxygen tension (> 55 mmHg, or 8%), similar to the red blood cell reservoir, the spleen.
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